蛍光標識ペプチドツールで見る膜タンパク質の自己会合挙動

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タイトル別名
  • Fluorescent Peptide Tools for Studying the Self-association of Membrane Proteins
  • Symposium Review 蛍光標識ペプチドツールで見る膜タンパク質の自己会合挙動
  • Symposium Review ケイコウ ヒョウシキ ペプチドツール デ ミル マク タンパクシツ ノ ジコ カイゴウ キョドウ

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<p>Detecting the behaviors of proteins in membranes is often challenging; we need to develop new methods to better understand the mechanisms involved. We have developed two types of peptide-based experimental systems that can detect the self-association of proteins in bilayer environments: 1) a single-pair fluorescence detection system for studying the self-association of transmembrane helices in model membranes; and 2) live-cell fluorescence labeling and analysis of the oligomeric state of membrane proteins using a coiled-coil labeling method. By using these methods, we show that membrane cholesterol significantly affects the self-association of transmembrane helices.</p>

収録刊行物

  • 薬学雑誌

    薬学雑誌 139 (2), 273-276, 2019-02-01

    公益社団法人 日本薬学会

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