Molecular and Cellular Network Systems Underlying Cold Tolerance of Caenorhabditis elegans

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Organisms are able to sense environmental information and must respond appropriately to live andproliferate. Information on environmental temperature is essential for organisms becausetemperature directly affects biochemical reactions and metabolism. Here, we review the molecularand physiological mechanisms responsible for cold tolerance and cold acclimation in a simplemodel animal, the nematode Caenorhabditis elegans. Recent molecular-biological studies andneural calcium-imaging analyses have revealed novel concepts of cold tolerance in this animal.Most significantly, a light-sensing neuron (ASJ) acts as temperature-sensing neuron that regulatesthe intestine and sperm in the cold-tolerance pathway. Sperm regulates cold tolerance throughnegative feedback onto this temperature-sensing neuron.


  • Cryobiology and Cryotechnology

    Cryobiology and Cryotechnology 64(2), 53-59, 2019

    Japanese Society of Cryobiology and Cryotechnology


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