Gemcitabine, Dexamethasone, and Cisplatin Regimen as an Effective Salvage Therapy for High-grade B-cell Lymphoma with <i>MYC</i> and <i>BCL2</i> and/or <i>BCL6</i> Rearrangements
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- Mitobe Masaki
- Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine, Niigata University, Japan
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- Kawamoto Keisuke
- Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine, Niigata University, Japan
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- Suzuki Takaharu
- Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine, Niigata University, Japan
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- Kiryu Maiko
- Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine, Niigata University, Japan
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- Tamura Suguru
- Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine, Niigata University, Japan
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- Nanba Ayako
- Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine, Niigata University, Japan
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- Suwabe Tatsuya
- Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine, Niigata University, Japan
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- Tanaka Tomoyuki
- Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine, Niigata University, Japan
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- Fuse Kyoko
- Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine, Niigata University, Japan
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- Shibasaki Yasuhiko
- Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine, Niigata University, Japan
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- Masuko Masayoshi
- Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine, Niigata University, Japan
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- Miyoshi Hiroaki
- Department of Pathology, School of Medicine, Kurume University, Japan
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- Ohshima Koichi
- Department of Pathology, School of Medicine, Kurume University, Japan
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- Sone Hirohito
- Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine, Niigata University, Japan
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- Takizawa Jun
- Department of Hematology, Endocrinology and Metabolism, Faculty of Medicine, Niigata University, Japan
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抄録
<p>A 61-year-old woman exhibited right inguinal lymphadenopathy and right lower limb edema approximately 1 month prior to hospitalization. She was diagnosed with high grade B-cell lymphoma, and a lymph node biopsy and fluorescence in situ hybridization indicated MYC, BCL2, and BCL6 rearrangements (triple-hit lymphoma). She had progressive disease that was CD20-negative after two courses of rituximab, cyclophosphamide, doxorubicin, vincristine, methotrexate/ifosfamide, etoposide, high-dose cytarabine (R-CODOX-M/IVAC) therapy. Subsequent etoposide, prednisolone, vincristine, cyclophosphamide, doxorubicin (EPOCH) therapy was not effective. However, after two cycles of gemcitabine, dexamethasone, and cisplatin (GDP) therapy, she achieved a complete response and was able to undergo autologous peripheral blood stem cell transplantation. GDP therapy may be effective as salvage therapy for chemotherapy-resistant triple-hit lymphoma. </p>
収録刊行物
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- Internal Medicine
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Internal Medicine 58 (4), 575-580, 2019-02-15
一般社団法人 日本内科学会