生物そのものを利用したバイオセンサ—線虫嗅覚によるがん診断—  [in Japanese] Bio-use sensors —Cancer diagnosis using C. elegans scent detection—  [in Japanese]

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Author(s)

    • 広津 崇亮 HIROTSU Takaaki
    • 九州大学大学院理学研究院生物科学部門 九州大学味覚・嗅覚センサ研究開発センター Department of Biology, Graduate School of Sciences, Kyushu University Division of Applied Medical Sensing, Research and Development Center for Taste and Odor Sensing, Kyushu University

Abstract

<p>微量のにおい物質の検知には,従来は物理・化学的手法が用いられてきたが,感度,選択性を追求すると大型化,高コスト化を招く問題があった.そこで近年注目されているのが,生物の嗅覚の高感度性,高選択性を生かしたバイオセンサである.その中には,生物の嗅覚機構を模倣するセンサ,生物の機構や設計思想を活用するセンサが含まれるが,本稿では生物そのものを利用するセンサについて紹介する.最近線虫<i>C. elegans</i>ががんのにおいを高精度に識別できることが発見された.線虫嗅覚を用いたがん診断技術(n-nose)は,高感度,低コスト,非侵襲性,簡便,早期がんを発見できるなど,これまでのがん検査システムを変える可能性を秘めている.</p>

<p>Chemical/physical technique has been used for the detection of a very small amount of odorants, but it has a problem that pursuing high sensitivity and selectivity causes upsizing and high costs. Therefore, in late years, the bio sensors which are based on the high sensitive and selective nature of olfactory systems of organisms attract attention. They includes bio-mimic and bio-inspired sensors. Here I introduce the bio-use sensor which employs animals themselves as sensors. Recently, it was reported nematode <i>C. elegans</i> can discriminate the smell of cancer with high accuracy. The cancer diagnosis technology using <i>C. elegans</i> scent detection (n-nose) is high accurate, low cost, noninvasive and easy, and can detect an early cancer. n-nose has the possibility to change a conventional cancer diagnosis system.</p>

Journal

  • Journal of Japan Association on Odor Environment

    Journal of Japan Association on Odor Environment 46(3), 191-199, 2015

    Japan Association on Odor Environment

Codes

  • NII Article ID (NAID)
    130007601938
  • NII NACSIS-CAT ID (NCID)
    AA11827805
  • Text Lang
    JPN
  • ISSN
    1348-2904
  • NDL Article ID
    026501712
  • NDL Call No.
    Z16-1560
  • Data Source
    NDL  J-STAGE 
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