Influence of Gradual Loading on Disuse Atrophy of the Rat Soleus Muscle Depends on the Longitudinal Site

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Other Title
  • 廃用性萎縮に対する漸増荷重がラットヒラメ筋に与える影響
  • 廃用性萎縮に対する漸増荷重がラットヒラメ筋に与える影響 : 長軸部位での検討
  • ハイヨウセイ イシュク ニ タイスル ゼンゾウ カジュウ ガ ラットヒラメキン ニ アタエル エイキョウ : チョウジク ブイ デ ノ ケントウ
  • ─長軸部位での検討─

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Abstract

<p>[Purpose] The purpose of this study was to verify the recovery after disuse atrophy by gradual loading. [Participants and Methods] Eight-week-old male Wistar rats were randomly assigned to control, hind-limb suspension (H), gradual loading after 7 days of hind-limb suspension (G), and constant loading after 7 days of hind-limb suspension (W) groups. At the end of the experimental period, the cross-sectional area and occurrence ratio of necrotic and central nuclear fibers were measured. [Results] The cross-sectional areas of the muscle fibers in the proximal region of the H and W groups were significantly smaller than those of the other groups, but there was no site-dependent difference in G group. [Conclusion] The results suggest gradual loading is an effective intervention for the proximal region which is the region most susceptible to disuse atrophy.</p>

Journal

  • Rigakuryoho Kagaku

    Rigakuryoho Kagaku 34 (1), 13-16, 2019

    The Society of Physical Therapy Science

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