Panax notoginseng Saponins Attenuate Oxygen-Glucose Deprivation/Reoxygenation-Induced Injury in Human SH-SY5Y Cells by Regulating the Expression of Inflammatory Factors through miR-155

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  • Meng Lanqing
    Department of Neurology, Affiliated Hospital of Youjiang Medical College for Nationalities
  • Lin Jun
    Department of Neurology, Affiliated Hospital of Youjiang Medical College for Nationalities
  • Huang Qing
    Department of Neurology, Affiliated Hospital of Youjiang Medical College for Nationalities
  • Liang Ping
    Department of Neurology, Affiliated Hospital of Youjiang Medical College for Nationalities
  • Huang Jianmin
    Department of Neurology, Affiliated Hospital of Youjiang Medical College for Nationalities
  • Jian Chongdong
    Department of Neurology, Affiliated Hospital of Youjiang Medical College for Nationalities
  • Lin Chong
    Department of Neurology, Affiliated Hospital of Youjiang Medical College for Nationalities
  • Li Xuebin
    Department of Neurology, Affiliated Hospital of Youjiang Medical College for Nationalities

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  • <i>Panax notoginseng</i> Saponins Attenuate Oxygen–Glucose Deprivation/Reoxygenation-Induced Injury in Human SH-SY5Y Cells by Regulating the Expression of Inflammatory Factors through miR-155

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<p>Panax notoginseng saponins (PNS) have been widely used in China to treat stroke. Accumulating evidence has found that microRNA (miR)-155 plays critical roles in the pathology of ischemic stroke. Here we investigated whether PNS plays a protective effect against oxygen–glucose deprivation/reoxygenation (OGD/R)-induced focal inflammation and injury in SH-SY5Y cells by regulating miR-155 expression. Treatment with PNS at a concentration less than 160 µg/mL had no effect on the proliferation of SH-SY5Y cell. In OGD/R-induced SH-SY5Y cells, 160 µg/mL PNS treatment promoted cell proliferation and cell cycle progression, as well as decreased inhibited apoptosis and miR-155 expression. However, overexpression of miR-155 attenuated the promotion effects of PNS on cell proliferation and cell cycle, apoptosis inhibition in OGD/R-induced SH-SY5Y cells. Moreover, 160 µg/mL PNS treatment decreased the levels of interleukin-1β (IL-1β), IL-6, and tumor necrosis factor-α (TNF-α) in OGD/R-induced SH-SY5Y cells, whereas overexpression of miR-155 reversed PNS-induced decreases in the levels of IL-1β, IL-6, and TNF-α in OGD/R-treated SH-SY5Y cells. In conclusion, PNS attenuated OGD/R-induced injury in human undifferentiated SH-SY5Y cells by regulating the expression of inflammatory factors through miR-155.</p>

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