Evaluation of gastric acid suppression with vonoprazan using calcium carbonate breath test

• Miyamoto Shuichi

  Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine

• Tsuda Momoko

  Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine

• Kato Mototsugu

  Department of Gastroenterology, National Hospital Organization Hakodate Hospital

• Mabe Katsuhiro

  Department of Gastroenterology, National Hospital Organization Hakodate Hospital

• Muto Shuichi

  Department of Gastroenterology, National Hospital Organization Hokkaido Medical Center

• Ono Shoko

  Division of Endoscopy, Hokkaido University Hospital

• Shimizu Yuichi

  Division of Endoscopy, Hokkaido University Hospital

• Sakamoto Naoya

  Department of Gastroenterology and Hepatology, Hokkaido University Graduate School of Medicine

Abstract

Vonoprazan, a potassium-competitive acid blocker, is a new class of acid-suppressing agent. The acid-inhibitory effect of vonoprazan has been well-documented. However, there is no report on the extent to which the amount of gastric acid secretion is suppressed, not pH measurement, by the use of vonoprazan. The aim of this study was to evaluate this suppression effect. This was a single-arm, interventional pilot study involving 7 healthy Japanese men. The subjects were administered 20 mg vonoprazan for 6 days. The amount of gastric acid secretion was determined using the calcium carbonate breath test. The acid outputs were defined as the maximum Δ¹³C‰ (Δ¹³C max) and area under the curve (AUC) during the 30 min sampling period. The Δ¹³C max and AUC values significantly decreased on the administration of 20 mg vonoprazan. The AUC dropped by approximately 78% on day 1 and by 84% on day 6 and subsequently returned to the control level after cessation of vonoprazan therapy (reduction by 68% on day 7 and by 42% on day 8). In conclusion, the amount of gastric acid secretion rapidly decreased by the administration of vonoprazan; this inhibitory effect was found to be potent and long-lasting. (UMIN ID: UMIN000025469)

Journal

• Journal of Clinical Biochemistry and Nutrition

  Journal of Clinical Biochemistry and Nutrition 64 (2), 174-179, 2019

  SOCIETY FOR FREE RADICAL RESEARCH JAPAN

Keywords

• vonoprazan
• gastric acid
• calcium carbonate breath test
• potassium-competitive acid blocker
• proton-pump inhibitors

Details

• CRID: 1390001288125497344
• NII Article ID: 130007605939
• DOI: 10.3164/jcbn.18-75
• ISSN: 18805086
• ISSN: 09120009
• Web Site: https://www.jstage.jst.go.jp/article/jcbn/64/2/64_18-75/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2020090610
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
• Abstract License Flag: Disallowed