Circulating Concentrations of Insulin Resistance-Associated Hepatokines, Selenoprotein P and Leukocyte Cell-Derived Chemotaxin 2, during an Oral Glucose Tolerance Test in Humans

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  • Mohri Kensuke
    Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences Department of System Biology, Kanazawa University Graduate School of Medical Sciences
  • Misu Hirofumi
    Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences PRESTO, Japan Science and Technology Agency
  • Takayama Hiroaki
    Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences Department of System Biology, Kanazawa University Graduate School of Medical Sciences
  • Ishii Kiyo-aki
    Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences Department of System Biology, Kanazawa University Graduate School of Medical Sciences
  • Kikuchi Akihiro
    Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences
  • Lan Fei
    Department of System Biology, Kanazawa University Graduate School of Medical Sciences Department of Endocrinology and Metabolism, Chengdu First People’s Hospital
  • Enyama Yasufumi
    Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences Department of System Biology, Kanazawa University Graduate School of Medical Sciences
  • Takeshita Yumie
    Department of System Biology, Kanazawa University Graduate School of Medical Sciences
  • Saito Yoshiro
    Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University Department of Medical Life Systems, Faculty of Life and Medical Sciences, Doshisha University
  • Kaneko Shuichi
    Department of System Biology, Kanazawa University Graduate School of Medical Sciences
  • Takamura Toshinari
    Department of Endocrinology and Metabolism, Kanazawa University Graduate School of Medical Sciences

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Abstract

<p>A hepatokine is a collective term for liver-derived secretory factors whose previously-unrecognized functions have been recently elucidated. We have rediscovered selenoprotein P (SeP) and leukocyte cell-derived chemotaxin 2 (LECT2) as hepatokines that are involved in the development of insulin resistance and hyperglycemia. The aim of this study was to determine whether and, if so, how oral glucose loading alters the two hepatokines in humans. We measured concentrations of serum SeP and plasma LECT2 during 75 g oral glucose tolerance test (OGTT) (n = 20) in people with various degrees of glucose tolerance. In OGTT, concentrations of both serum SeP and plasma LECT2 decreased at 120 min compared with the baseline values, irrespective of the severity of glucose intolerance. Decrement of serum SeP during OGTT showed no correlations to the clinical parameters associated with insulin resistance or insulin secretion. In multiple stepwise regression analyses, plasma cortisol was selected as the variable to explain the changes in plasma concentrations of LECT2. The current data reveal the acute inhibitory actions of oral intake of glucose on circulating SeP and LECT2 in humans, irrespective of the severity of glucose intolerance. This study suggests that circulating SeP is regulated by the unknown clinical factors other than insulin and glucose during OGTT.</p>

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