The Prospective Association Between Plasma Concentrations of Cellular Growth Factors and Risk of Heart Failure Mortality in Japanese Population

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    • Eshak Ehab S
    • Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine|Department of Public Health and Preventive Medicine, Faculty of Medicine, Minia University
    • Maruyama Koutatsu
    • Laboratory of Community Health and Nutrition, Special Course of Food and Health Science Department of Bioscience, Graduate School of Agriculture, Ehime University
    • Iso Hiroyasu
    • Public Health, Department of Social Medicine, Osaka University Graduate School of Medicine
    • Tamakoshi Akiko
    • Department of Public Health, Faculty of Medicine, Hokkaido University


<p><b>Background:</b> Limited evidence is available on the association of insulin-like growth factors (IGFs) and risk of heart failure in population-based samples. We investigated whether serum IGFs concentrations can predict mortality from heart failure.</p><p><b>Methods:</b> We conducted a nested case-control study of 39,242 subjects aged 40–79 years who participated in the JACC study, a large Japanese prospective cohort study; participants provided serum samples and were followed up for 9 years. In heart failure cases and age-, sex-, community-, and year of blood withdrawal-matched controls, we measured serum concentrations of IGF-I, IGF-II, and IGF binding protein 3 (IGFBP3) and transforming growth factor (TGF-β1).</p><p><b>Results:</b> During the follow-up, there were 88 heart failure deaths (44 men and 44 women). Each increment of 1 standard deviation [SD] of IGF-II (120.0 ng/mL in women and 143.7 ng/mL in men) was associated with a 47% reduced risk of mortality from heart failure; multivariable odds ratio was 0.53 (95% confidence interval [CI], 0.30–0.94, <i>P</i>-trend = 0.03). The multivariable odds ratio in the highest quartile of IGFBP3 serum concentrations (≥3.29 µg/mL in women and ≥3.31 µg/mL in men) compared with the lowest (<2.11 µg/mL in women and <2.56 µg/mL in men) was 0.24 (95% CI, 0.05–1.11; <i>P</i>-trend = 0.12). No association was found between serum concentrations of IGF-I or TGF-β1 and risk of heart failure.</p><p><b>Conclusions:</b> Higher serum concentrations of IGF-II were associated with lower mortality from heart failure, which might suggest a possible role of IGF-II in the occurrence or prognosis of heart failure.</p>


  • Journal of Epidemiology

    Journal of Epidemiology 29(3), 104-109, 2019

    Japan Epidemiological Association


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