Angiotensin II, Oxidative Stress, and Sympathetic Nervous System Hyperactivity in Heart Failure

• Koba Satoshi

  Division of Integrative Physiology, Department of Physiology, School of Medicine, Tottori University Faculty of Medicine, Yonago 683-8503, Japan

抄録

In congestive heart failure (CHF), sympathetic nervous system is hyperactive. This article reviews current understandings about central and peripheral neural mechanisms underlying sympathetic hyperactivation in this pathological condition. During the development of CHF, renin-angiotensin system (RAS) activities and angiotensin II–mediated oxidative stress become enhanced. Here, on the basis of findings obtained from animal studies, it is examined how RAS overactivation and oxidative stress in central and peripheral nervous systems of CHF mediate sympathetic hyperactivation. Mechanisms by which exercise training in CHF ameliorates RAS overactivation, oxidative stress and sympathetic hyperactivation are also investigated.

収録刊行物

• Yonago Acta Medica

  Yonago Acta Medica 61 (2), 103-109, 2018

  ヨナゴ・アクタ・メディカ刊行会

キーワード

• General Medicine

詳細情報

• CRID: 1390845713057037952
• NII論文ID: 130007613079
• NII書誌ID: AA00892882
• DOI: 10.33160/yam.2018.06.002
• ISSN: 13468049
• ISSN: 05135710
• Web Site: https://repository.lib.tottori-u.ac.jp/records/4820
• Web Site: https://www.jstage.jst.go.jp/article/yam/61/2/61_2018.06.002/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2019301669
• 本文言語コード: en
• データソース種別:
  • JaLC
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可