Community-acquired Disseminated <i>Exophiala dermatitidis</i> Mycosis with Necrotizing Fasciitis in Chronic Graft-versus-host Disease
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- Sato Eiichi
- Division of Medical Oncology, Hematology, and Infectious Diseases, Department of Internal Medicine, Fukuoka University Hospital, Japan
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- Togawa Atsushi
- Division of Medical Oncology, Hematology, and Infectious Diseases, Department of Internal Medicine, Fukuoka University Hospital, Japan
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- Masaki Michio
- Division of Medical Oncology, Hematology, and Infectious Diseases, Department of Internal Medicine, Fukuoka University Hospital, Japan
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- Shirahashi Akihiko
- Division of Medical Oncology, Hematology, and Infectious Diseases, Department of Internal Medicine, Fukuoka University Hospital, Japan
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- Kumagawa Midori
- Division of Medical Oncology, Hematology, and Infectious Diseases, Department of Internal Medicine, Fukuoka University Hospital, Japan Department of Blood Transfusion, Fukuoka University Hospital, Japan
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- Kawano Yasumasa
- Department of Emergency and Critical Care Medicine, Fukuoka University Hospital, Japan
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- Ishikura Hiroyasu
- Department of Emergency and Critical Care Medicine, Fukuoka University Hospital, Japan
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- Yamashiro Yuri
- Department of Plastic and Reconstructive Surgery, Fukuoka University Hospital, Japan
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- Takagi Satoshi
- Department of Plastic and Reconstructive Surgery, Fukuoka University Hospital, Japan
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- To Hiromi
- Department of Clinical Laboratory Medicine, Fukuoka University Hospital, Japan
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- Kobata Katsumi
- Department of Pathology, Fukuoka University Hospital, Japan
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- Takeshita Morishige
- Department of Pathology, Fukuoka University Hospital, Japan
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- Kusaba Koji
- Department of Laboratory Medicine, Saga University Hospital, Japan
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- Sueoka Eisaburo
- Department of Laboratory Medicine, Saga University Hospital, Japan
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- Tamura Kazuo
- Division of Medical Oncology, Hematology, and Infectious Diseases, Department of Internal Medicine, Fukuoka University Hospital, Japan
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- Takamatsu Yasushi
- Division of Medical Oncology, Hematology, and Infectious Diseases, Department of Internal Medicine, Fukuoka University Hospital, Japan
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- Takata Tohru
- Division of Medical Oncology, Hematology, and Infectious Diseases, Department of Internal Medicine, Fukuoka University Hospital, Japan Department of Infection Control, Fukuoka University Hospital, Japan
Bibliographic Information
- Other Title
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- Community-acquired disseminated Exophiala dermatitidis mycosis with necrotizing fasciitis in chronic graft-versus-host disease
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Abstract
<p>We herein report a case of systemic phaeohyphomycosis by Exophiala dermatitidis (E. dermatitidis) with chronic graft-versus-host disease (GVHD) after allogeneic hematopoietic stem cell transplantation (HSCT). The patient had been taking oral corticosteroids for years to control the GVHD. Yeast-like fungi were identified in a blood culture, so treatment with micafungin (150 mg/day) was begun, with no improvement. The patient passed away on hospital Day 12. A sequence analysis of rRNA revealed the isolate to be E. dermatitidis. This report brings attention to an emerging mycosis of community-acquired Exophiala species infection in the very-late phase after allogenic HSCT in patients with chronic GVHD. </p>
Journal
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- Internal Medicine
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Internal Medicine 58 (6), 877-882, 2019-03-15
The Japanese Society of Internal Medicine