膜内切断プロテアーゼの基質認識・切断機構  [in Japanese] Substrate Recognition and Cleavage Mechanism of Intramembrane-Cleaving Protease  [in Japanese]

Access this Article

Author(s)

Abstract

<p>Intramembrane-cleaving proteases (I-CLiPs) are a unique class of proteases, which catalyze proteolysis of target membrane proteins within the lipid bilayer. I-CLiPs are found in all kingdoms of life and are involved in various cellular processes such as stress responses, lipid homeostasis, induction of apoptosis and bacterial virulence. RseP, an <i>Escherichia coli</i> I-CLiP, plays a critical role in the extracytoplasmic stress response essential for bacterial survival. In this review, I will summarize the results of our recent studies on the structure and function of RseP and propose a model of the substrate recognition and cleavage by this peculiar protease.</p>

Journal

  • Seibutsu Butsuri

    Seibutsu Butsuri 59(2), 079-083, 2019

    The Biophysical Society of Japan General Incorporated Association

Codes

  • NII Article ID (NAID)
    130007620424
  • NII NACSIS-CAT ID (NCID)
    AN00129693
  • Text Lang
    JPN
  • ISSN
    0582-4052
  • NDL Article ID
    029663771
  • NDL Call No.
    Z18-49
  • Data Source
    NDL  J-STAGE 
Page Top