糖質の認識によりキラルならせんを巻く芳香族フォルダマー

• 阿部 肇

  富山大学大学院医学薬学研究部

書誌事項

タイトル別名

• Aromatic Foldamers Recognizing Saccharides to Form Chiral Helices
• Symposium Review 糖質の認識によりキラルならせんを巻く芳香族フォルダマー
• Symposium Review トウシツ ノ ニンシキ ニ ヨリ キラル ナ ラセン オ マク ホウコウゾク フォルダマー

抄録

New meta-arylene ethynylene foldamers were developed by employing pyridine and phenol units. These demonstrated interesting properties related to the hydrogen-bonding behavior of the arylene units. Pyridine-acetylene-phenol foldamers showed improved saccharide recognition abilities compared with pyridine-acetylene foldamers with no phenol units. Solid-liquid extraction could be achieved due to the strong binding. Hydrocarbon stapling by alkene metathesis under templation was attempted, and the helical structure was efficiently stabilized. Phenol-acetylene oligomers spontaneously formed helical structures via intramolecular hydrogen bonding. The helical sense could be biased by adding chiral amines.

収録刊行物

• 薬学雑誌

  薬学雑誌 139 (4), 591-598, 2019-04-01

  公益社団法人 日本薬学会

キーワード

• helical foldamer
• saccharide recognition
• hydrogen bonding
• pyridine
• phenol

詳細情報

• CRID: 1390845713073791744
• NII論文ID: 130007621599
• NII書誌ID: AN00284903
• DOI: 10.1248/yakushi.18-00179-2
• ISSN: 13475231
• ISSN: 00316903
• NDL書誌ID: 029633944
• PubMed: 30930394
• Web Site: http://id.ndl.go.jp/bib/029633944
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I029633944
• Web Site: https://www.jstage.jst.go.jp/article/yakushi/139/4/139_18-00179-2/_pdf
• 本文言語コード: ja
• データソース種別:
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  • Crossref
  • PubMed
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  • KAKEN
• 抄録ライセンスフラグ: 使用不可