DNA Damage and Senescence-Associated Inflammation in Cardiovascular Disease

この論文にアクセスする

著者

抄録

<p>DNA suffers various types of damage even in a normal condition, although they are rapidly repaired by mechanisms called DNA repair. Most progeroid syndromes are caused by genetic defects in specific molecules involved in the DNA repair. DNA damage activates a broad range of signaling pathway that leads to repair, cell cycle arrest, apoptosis and so on, which is called DNA damage response. Recent studies revealed that persistent DNA damage response triggers induction of cell senescence and senescence-associated secretory phenotype (SASP). Here, we review recent advances in the understanding of the molecular mechanisms by which SASP components are regulated, and discuss the possible roles of DNA damage and the DNA damage response, and SASP in the pathogenesis of cardiovascular disease.</p>

収録刊行物

  • Biological & Pharmaceutical Bulletin

    Biological & Pharmaceutical Bulletin 42(4), 531-537, 2019

    公益社団法人 日本薬学会

各種コード

  • NII論文ID(NAID)
    130007622128
  • NII書誌ID(NCID)
    AA10885497
  • 本文言語コード
    ENG
  • ISSN
    0918-6158
  • NDL 記事登録ID
    029603957
  • NDL 請求記号
    Z53-V41
  • データ提供元
    NDL  J-STAGE 
ページトップへ