Mutant Frequency is not Increased in Mice Orally Exposed to Sodium Dichromate

• Aoki Yasunobu

  National Institute for Environmental Studies, Center for Health and Environmental Risk Research, Tsukuba, Japan

• Matsumoto Michiyo

  National Institute for Environmental Studies, Center for Health and Environmental Risk Research, Tsukuba, Japan

• Matsumoto Michi

  National Institute for Environmental Studies, Center for Health and Environmental Risk Research, Tsukuba, Japan

• Masumura Kenichi

  National Institute of Health Sciences, Division of Genetics and Mutagenesis, Kawasaki, Japan

• Nohmi Takehiko

  National Institute of Health Sciences, Division of Genetics and Mutagenesis, Kawasaki, Japan

Abstract

The in vivo mutagenicity of hexavalent chromium in the small intestine, the target organ of tumorgenicity, was examined by means of a transgenic mouse gene mutation assay. Sodium dichromate dihydrate was administered orally in drinking water to male gpt delta mice at a dose of 85.7 or 257.4 mg/L for 28 days or at a dose of 8.6, 28.6 or 85.7 mg/L for 90 days. No significant increase in gpt mutant frequency relative to that in control mice was observed in the small intestine in either the 28- or 90-day study, whereas 28-day oral administration of potassium bromate, a positive control substance, increased mutant frequency.

Journal

• Food Safety

  Food Safety 7 (1), 2-10, 2019

  Food Safety Commission, Cabinet Office, Government of Japan

Keywords

• genotoxicity
• hexavalent chromium
• in vivo mutagenesis
• small intestine
• transgenic rodent gene mutation assay
• tumor

Details

• CRID: 1390845713072644096
• NII Article ID: 130007627483
• DOI: 10.14252/foodsafetyfscj.2018014
• ISSN: 21878404
• Web Site: https://www.jstage.jst.go.jp/article/foodsafetyfscj/7/1/7_2018014/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2020029012
• Text Lang: en
• Data Source:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed