Is the Oil | Water Interface the Simplest and Best Suited Model for Understanding Biomembranes?

• OSAKAI Toshiyuki

  Department of Chemistry, Graduate School of Science, Kobe University

Bibliographic Information

Other Title

• Water Interface the Simplest and Best Suited Model for Understanding Biomembranes?

Abstract

Many studies have been conducted by using the oil (O) | water (W) interface as a simple model for understanding ion transfer (IT) or electron transfer (ET) across biomembranes. In this review, we revisit the usability of the O | W interface as a biomembrane model. For understanding biomembrane IT, the O | W interface is the simplest and best suited model. For example, the standard Gibbs transfer energy of drug ions at the O | W interface is a useful measure for evaluating their membrane permeability in a conventional in vitro assay, called PAMPA. However, the O | W interface is not necessarily a good model for understanding biomembrane ET. This is because no net current can be observed with the O | W interface, owing to the ET-coupled proton transfer. In such a case, the self-assembled monolayer (SAM) formed on a metal electrode serves as a better model for understanding biomembrane ET.

Journal

• Analytical Sciences

  Analytical Sciences 35 (4), 361-366, 2019-04-10

  The Japan Society for Analytical Chemistry

Keywords

• Oil | water interface
• ion transfer
• electron transfer
• biomembrane model
• non-Bornian model
• self-assembled monolayer

Details

• CRID: 1390001288129621632
• NII Article ID: 130007629981
• NII Book ID: AA10500785
• DOI: 10.2116/analsci.18r005
• ISSN: 13482246
• ISSN: 09106340
• NDL BIB ID: 029625984
• PubMed: 30606904
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I029625984
• Web Site: https://link.springer.com/content/pdf/10.2116/analsci.18R005.pdf
• Web Site: https://link.springer.com/article/10.2116/analsci.18R005/fulltext.html
• Web Site: https://www.jstage.jst.go.jp/article/analsci/35/4/35_18R005/_pdf
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed