Simple Electrocardiographic Score Can Predict Left Ventricular Reverse Remodeling in Patients With Non-Ischemic Cardiomyopathy

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著者

    • Konishi Shozo
    • Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine
    • Kanzaki Machiko
    • Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine
    • Tsukamoto Yasumasa
    • Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine
    • Hikoso Shungo
    • Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine
    • Sakata Yasushi
    • Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine
    • Ohtani Tomohito
    • Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine
    • Mizuno Hiroya
    • Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine
    • Sera Fusako
    • Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine
    • Nakamoto Kei
    • Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine
    • Chimura Misato
    • Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine
    • Sengoku Kaoruko
    • Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine
    • Miyawaki Hiroshi
    • Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine
    • Higuchi Rie
    • Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine

抄録

<p><b><i>Background: </i></b>Left ventricular reverse remodeling (LVRR) is a favorable response in non-ischemic, non-valvular cardiomyopathy (NICM) patients. Recently, 18-lead body surface electrocardiography (ECG), the standard 12-lead ECG with synthesized right-sided/posterior chest leads, has been developed, but its predictive value for LVRR has not been evaluated. </p><p><b><i>Methods and Results: </i></b>Of 216 consecutive hospitalized NICM patients with LV ejection fraction (LVEF) ≤35%, we studied 125 who received optimization of their heart failure treatment and had 18-lead ECG and echocardiography data available for evaluating LVRR, defined as an absolute increase in LVEF ≥10% concomitant with LVEF ≥35% after 1-year optimized treatment. Most 18-lead ECG parameters in the NICM patients differed from those in 312 age- and body mass index-matched subjects with normal echocardiography. LVRR occurred in 59 NICM patients and they had a larger QRS amplitude in the limb leads (I, II, aVR, and aVF), precordial leads (V3–V6), and synthesized leads (syn-V4R–5R), decreased QRS axis and duration, and lower prevalence of fragmented QRS than those without LVRR. The ECG score using 3 selected parameters (QRS amplitude in aVR ≥675 µV; QRS duration <106 ms without fragmentation; and QRS axis <67°) was associated with the incidence of LVRR even after adjusting for optimized treatment. </p><p><b><i>Conclusions: </i></b>The standard 12-lead ECG parameters are sufficiently predictive of LVRR in NICM patients. </p>

収録刊行物

  • Circulation Reports

    Circulation Reports 1(4), 171-178, 2019

    一般社団法人 日本循環器学会

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