Calcium Phosphate Coating Using Supersaturated Solutions for Biomedical Applications

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  • OYANE Ayako
    Nanomaterials Research Institute, National Institute of Advanced Industrial Science and Technology (AIST)

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Other Title
  • 過飽和溶液を利用したリン酸カルシウム成膜とバイオメディカル応用
  • カホウワ ヨウエキ オ リヨウ シタ リンサン カルシウムセイマク ト バイオメディカル オウヨウ

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Abstract

<p>Calcium phosphate (CaP) coating on artificial materials helps to improve their biocompatibility and osteoconductivity. This review describes our biomimetic CaP coating processes using supersaturated CaP solutions. In the precursor-assisted biomimetic process, a substrate is initially pre-coated with amorphous CaP by alternately dipping in the calcium and phosphate solutions ; this is followed by the immersion of the substrate in a supersaturated CaP solution. This process effectively coats the entire surface of a porous material. In the laser-assisted biomimetic process, a substrate is irradiated using weak pulsed laser light in a supersaturated CaP solution. This process enables quick (<30 min) and area-specific CaP coating. By utilizing the aforementioned processes, various cell-stimulating substances, such as DNA, proteins, and trace elements, can be immobilized within the CaP coatings. Depending on the selection of cell-stimulating substances and processing conditions, the coatings can be designed to perform different biological functions. Our coating processes can be potentially used in several biomedical applications including bone tissue engineering and tooth surface modification.</p>

Journal

  • Vacuum and Surface Science

    Vacuum and Surface Science 62 (4), 217-222, 2019-04-10

    The Japan Society of Vacuum and Surface Science

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