老化研究のためのモデルマウス―老化促進モデルマウスを軸にして―  [in Japanese] The senescence-accelerated mouse as a model for geriatrics and aging biology  [in Japanese]

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Author(s)

    • 森 政之 Mori Masayuki
    • 信州大学 学術研究院 先鋭領域融合研究群バイオメディカル研究所 先端疾患予防学部門 Department of Advanced Medicine for Health Promotion, Institute for Biomedical Sciences, Interdisciplinary Cluster for Cutting Edge Research, Shinshu University
    • 樋口 京一 Higuchi Keiichi
    • 信州大学 学術研究院 先鋭領域融合研究群バイオメディカル研究所 神経難病学部門 Department of Biological Sciences for Intractable Neurological Diseases, Institute for Biomedical Sciences, Interdisciplinary Cluster for Cutting Edge Research, Shinshu University

Abstract

<p>世界的に高齢者人口の急速な増加が予測されている状況下,「健康で活動的な人生の期間を可能な限り延長する」という医学研究の最終目標を達成するためには,ヒトの〝老化〟の基本的なメカニズムの生物学的理解,および,老化に伴い発症する様々な〝老化関連疾患〟の発症機序の医学的解明が重要な課題である.老化促進モデルマウス(senescence-accelerated mouse:SAM)は一群の近交系マウス系統で,このうちSAMP系統は共通して促進老化と短寿命を呈する.同時に,老化アミロイド症,老年性骨粗鬆症,学習・記憶障害など,ヒトに類似した様々な老化関連疾患をそれぞれの系統特異的に示すことから老化研究に有用なモデル動物として広く利用されている.本稿ではSAMマウスの特性,およびSAMマウスを用いた基礎ならびに応用研究の現状を紹介する.</p>

<p>Rapid expansion of aged population is predicted worldwide. To cope with problems expected from this situation and extend the period of active and healthy life of people as much as possible, it is important to elucidate not only the biological mechanisms of "aging", but also the etiology of various "age-related diseases". To attain this goal, extensive studies using excellent animal models are indispensable. Senescence-accelerated mouse (SAM) is a series of inbred mouse strains that includes SAMP1, SAMP6, SAMP8, SAMP10, and SAMR1. SAMP strains exhibit accelerated senescence and short lifespan. In addition, each strain shows specific age-related disease phenotypes which are similar to symptoms observed in humans, such as senile amyloidosis (SAMP1), senile osteoporosis (SAMP6), and age-dependent deficits in learning and memory (SAMP8), making SAM mice useful for an aging research. In this review, we introduce the characteristics and application of SAM in geriatrics and aging biology.</p>

Journal

  • Folia Pharmacologica Japonica

    Folia Pharmacologica Japonica 153(4), 179-185, 2019

    The Japanese Pharmacological Society

Codes

  • NII Article ID (NAID)
    130007630615
  • NII NACSIS-CAT ID (NCID)
    AN00198335
  • Text Lang
    JPN
  • ISSN
    0015-5691
  • NDL Article ID
    029628652
  • NDL Call No.
    Z19-247
  • Data Source
    NDL  J-STAGE 
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