Metastatic Malignant Lymphoma Mimicking Cerebral Toxoplasmosis with the "Target Sign"
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- Ueno Hiroki
- Department of Clinical Neuroscience and Therapeutics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan
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- Norose Kazumi
- Department of Infection and Host Defense, Graduate School of Medicine, Chiba University, Japan
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- Kamimura Teppei
- Department of Clinical Neuroscience and Therapeutics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan
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- Mihara Keichiro
- Department of Hematology and Oncology, Research Institute for Radiation Biology and Medicine, Hiroshima University, Japan
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- Yamasaki Fumiyuki
- Department of Neurosurgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan
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- Hikosaka Kenji
- Department of Infection and Host Defense, Graduate School of Medicine, Chiba University, Japan
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- J. Amatya Vishwa
- Department of Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan
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- Takeshima Yukio
- Department of Pathology, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan
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- Kurisu Kaoru
- Department of Neurosurgery, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan
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- Maruyama Hirofumi
- Department of Clinical Neuroscience and Therapeutics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Japan
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Abstract
<p>We herein report the case of a 60-year-old man with a "target sign" in the left frontal lobe on magnetic resonance imaging (MRI), which is thought to be a specific sign of cerebral toxoplasmosis. 18F-fluorodeoxyglucose-positron emission tomography showed no increased uptake, and 201Tl-single photon emission computed tomography showed the focal uptake in the left frontal lesion. On a brain biopsy, the patient was given a definitive diagnosis of brain metastasis from diffuse large B-cell lymphoma, and cerebral toxoplasmosis was excluded. In the present case, multilayer intensities on MRI may reflect the fast-growing nature of this tumor. </p>
Journal
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- Internal Medicine
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Internal Medicine 58 (8), 1157-1162, 2019-04-15
The Japanese Society of Internal Medicine