Hashimoto's Encephalopathy Presenting with Smoldering Limbic Encephalitis
-
- Nagano Masahiro
- Department of Neurology, Kyoto University Graduate School of Medicine, Japan
-
- Kobayashi Katsuya
- Department of Neurology, Kyoto University Graduate School of Medicine, Japan
-
- Yamada-Otani Mayumi
- Department of Neurology, Kyoto University Graduate School of Medicine, Japan
-
- Kuzuya Akira
- Department of Neurology, Kyoto University Graduate School of Medicine, Japan
-
- Matsumoto Riki
- Department of Neurology, Kyoto University Graduate School of Medicine, Japan
-
- Oita Jiro
- Department of Neurology, Shimizu Hospital, Japan
-
- Yoneda Makoto
- Faculty of Nursing and Social Welfare Sciences, Fukui Prefectural University, Japan
-
- Ikeda Akio
- Department of Epilepsy, Movement Disorders and Physiology, Kyoto University Graduate School of Medicine, Japan
-
- Takahashi Ryosuke
- Department of Neurology, Kyoto University Graduate School of Medicine, Japan
Search this article
Abstract
<p>Hashimoto's encephalopathy (HE) is a steroid-responsive autoimmune encephalopathy associated with Hashimoto thyroiditis. We herein report a case of HE manifesting "smoldering" limbic encephalitis with persisting symptoms and abnormalities on examinations. Although our patient experienced partial clinical remission after treatment, hippocampal hypermetabolism on [18F] fluorodeoxyglucose positron emission tomography (FDG-PET) and subclinical seizures on video electroencephalography persisted. Hypermetabolism on FDG-PET was improved by additional prednisolone therapy. Thus, as with other autoimmune limbic encephalitis cases, HE can take a course of "smoldering" encephalitis. FDG-PET and electroencephalogram findings can reflect the disease activity degree in such patients, although with certain neurophysiological and biochemical distinctions. </p>
Journal
-
- Internal Medicine
-
Internal Medicine 58 (8), 1167-1172, 2019-04-15
The Japanese Society of Internal Medicine