Significance of IgG4-positive cells in severe eosinophilic chronic rhinosinusitis

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Author(s)

    • Koyama Takahisa
    • Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
    • Orita Yorihisa
    • Department of Otolaryngology-Head and Neck Surgery, Kumamoto University
    • Kanai Kengo
    • Department of Otorhinolaryngology-Head & Neck Surgery, Kagawa Prefectural Central Hospital
    • Taniguchi Masami
    • Clinical Research Center for Allergy and Rheumatology, National Hospital Organization Sagamihara National Hospital
    • Nishizaki Kazunori
    • Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
    • Okano Mitsuhiro
    • Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences|Department of Otorhinolaryngology, International University of Health and Welfare School of Medicine
    • Kariya Shin
    • Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
    • Sato Yasuharu
    • Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences|Division of Pathophysiology, Okayama University Graduate School of Health Sciences
    • Gion Yuka
    • Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences|Division of Pathophysiology, Okayama University Graduate School of Health Sciences
    • Higaki Takaya
    • Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
    • Haruna Takenori
    • Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
    • Fujiwara Tazuko
    • Department of Otolaryngology-Head & Neck Surgery, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences
    • Minoura Akira
    • Department of Public Health, Showa University School of Medicine
    • Takao Soshi
    • Department of Epidemiology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

Abstract

<p><i>Background:</i> IgG4 production is regulated by type 2 (IL-4 and IL-13) and regulatory (IL-10) cytokines involved in the pathophysiology of chronic rhinosinusitis (CRS). We sought to determine the pathophysiological characteristics of IgG4-positive cells in sinonasal tissues in CRS, especially eosinophilic CRS (ECRS).</p><p><i>Methods:</i> IgG4-positive cells in uncinate tissues (UT) and nasal polyps (NP) were examined by immunohistochemistry. Associations between the number of IgG4-positive cells and clinicopathological factors were analyzed. Receiver operating characteristics (ROC) analysis was performed to determine the cut-off value of IgG4-positive cells in tissue that can predict the post-operative course.</p><p><i>Results:</i> IgG4 was mainly expressed in infiltrating plasma and plasmacytoid cells, and the number of IgG4-positive cells was significantly higher in NP, especially those from severe ECRS patients, than in UT. In CRS patients, the number of IgG4-positive cells significantly and positively correlated with blood and tissue eosinophilia, radiological severity, and serum level of total IgE. The number of infiltrating IgG4-positive cells was significantly higher in patients with a poor post-operative course (sustained sinus shadow 6 months after surgery) than in those with a good one. The number of IgG4-positive cells in NP could discriminate patients with a good or a poor post-operative course (area under the curve: 0.769). Also, 73.3% sensitivity and 82.5% specificity were achieved when the cut-off value was set at 17 cells/high-power field.</p><p><i>Conclusions:</i> Our results suggest that the local expression of IgG4 on cells may be used as a biomarker that reflects the pathophysiology of CRS, including the post-operative course.</p>

Journal

  • Allergology International

    Allergology International 68(2), 216-224, 2019

    Elsevier

Codes

  • NII Article ID (NAID)
    130007633578
  • NII NACSIS-CAT ID (NCID)
    AA11091750
  • Text Lang
    ENG
  • Article Type
    journal article
  • ISSN
    1323-8930
  • Data Source
    IR  J-STAGE 
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