Severity scales of non-IgE-mediated gastrointestinal food allergies in neonates and infants

• Yagi Hisako

  Department of Pediatrics, Gunma University Graduate School of Medicine

• Takizawa Takumi

  Department of Pediatrics, Gunma University Graduate School of Medicine

• Sato Koichiro

  Department of Pediatrics, Gunma University Graduate School of Medicine

• Inoue Takaharu

  Department of Pediatrics, Gunma University Graduate School of Medicine

• Nishida Yutaka

  Department of Pediatrics, Gunma University Graduate School of Medicine

• Ishige Takashi

  Department of Pediatrics, Gunma University Graduate School of Medicine

• Tatsuki Maiko

  Department of Pediatrics, Gunma University Graduate School of Medicine

• Hatori Reiko

  Department of Pediatrics, Gunma University Graduate School of Medicine

• Kobayashi Yasuko

  Department of Pediatrics, Gunma University Graduate School of Medicine

• Yamada Yoshiyuki

  Divisions of Allergy and Immunology, Gunma Children's Medical Center

• Arakawa Hirokazu

  Department of Pediatrics, Gunma University Graduate School of Medicine

抄録

Background: Non-IgE-mediated gastrointestinal food allergies (non-IgE-GI-FAs) are one type of food allergy found in neonates and infants. Few reports have defined the severity of non-IgE-GI-FAs in these populations. Methods: Grading scales of the severity of non-IgE-GI-FAs according to extra-GI symptoms, such as poor weight gain, as well as systemic symptoms, including fever and shock, were developed and retrospectively applied to patients with non-IgE-GI-FAs. The relationship between the severity of non-IgE-GI-FAs and both clinical and laboratory findings were examined. Results: Elevation of C-reactive protein levels and a decrease in total protein and albumin were observed in accordance with allergy severity. In an endoscopic examination, inflammatory findings were confirmed in large areas of the colonic mucosa in case of higher severity levels, and infiltration of inflammatory cells other than eosinophils was found in the severest grade. Extensively hydrolyzed milk or amino acid-based milk was required for all patients with the severest grade. In addition, the timing of acquiring tolerance tended to be late for this grade. Conclusions: Classification and determination of the severity of non-IgE-GI-FAs in neonates and infants may not only contribute to elucidation of the pathogenesis but may also be useful in the clinical setting.

収録刊行物

• Allergology International

  Allergology International 68 (2), 178-184, 2019

  一般社団法人日本アレルギー学会

キーワード

• Food hypersensitivity
• Gastroenteritis
• Infant
• Milk
• Prognosis

詳細情報

• CRID: 1390282763108958208
• NII論文ID: 130007633592
• DOI: 10.1016/j.alit.2018.08.004
• ISSN: 14401592
• ISSN: 13238930
• Web Site: https://api.elsevier.com/content/article/PII:S1323893018301011?httpAccept=text/xml
• Web Site: https://api.elsevier.com/content/article/PII:S1323893018301011?httpAccept=text/plain
• Web Site: https://search.jamas.or.jp/link/ui/2020203866
• 本文言語コード: en
• データソース種別:
  • JaLC
  • Crossref
  • CiNii Articles
  • KAKEN
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