Usefulness of Ustekinumab for Treating a Case of Myelodysplastic Syndrome-Associated Inflammatory Bowel Disease

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Author(s)

    • Kono Masashi
    • Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Japan
    • Hagiwara Satoru
    • Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Japan
    • Watanabe Tomohiro
    • Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Japan
    • Nishida Naoshi
    • Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Japan
    • Enoki Eisuke
    • Department of Pathology, Kindai University Faculty of Medicine, Japan
    • Inoue Hiroaki
    • Department of Hematology and Rheumatology, Kindai University Faculty of Medicine, Japan
    • Matsumura Itaru
    • Department of Hematology and Rheumatology, Kindai University Faculty of Medicine, Japan
    • Kudo Masatoshi
    • Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Japan
    • Sakurai Toshiharu
    • Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Japan
    • Okamoto Kazuki
    • Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Japan
    • Nagai Tomoyuki
    • Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Japan
    • Komeda Yoriaki
    • Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Japan
    • Kashida Hiroshi
    • Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Japan
    • Minaga Kosuke
    • Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Japan
    • Kamata Ken
    • Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Japan
    • Takenaka Mamoru
    • Department of Gastroenterology and Hepatology, Kindai University Faculty of Medicine, Japan

Abstract

<p>Autoimmune diseases including inflammatory bowel disease (IBD) occur in association with myelodysplastic syndrome (MDS). MDS-associated IBD frequently demonstrates a complicated course. We herein report the first case with MDS-associated IBD that was successfully treated with ustekinumab (UST), an anti-interleukin (IL) 12/23p40 monoclonal antibody. A 63-year-old man with a 7-year history of MDS was referred for examination of diarrhea, abdominal pain and fever. A blood examination revealed a marked elevation of C-reactive protein. Colonoscopy showed multiple ulcers in the terminal ileum. He was resistant to anti-TNF-α antibody and azacitidine. Subsequently, UST treatment reduced colonic IL-17 and IL-6 expression and the patient currently maintains a state of remission. </p>

Journal

  • Internal Medicine

    Internal Medicine, 2019

    The Japanese Society of Internal Medicine

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