Elevated Serum Elaidic Acid Predicts Risk of Repeat Revascularization After Percutaneous Coronary Intervention in Japan

• Oshita Toshihiko

  Division of Cardiovascular Medicine, Kobe University Graduate School of Medicine

• Toh Ryuji

  Division of Evidence-based Laboratory Medicine, Kobe University Graduate School of Medicine

• Shinohara Masakazu

  Division of Epidemiology, Kobe University Graduate School of Medicine

• Mori Kenta

  Department of General Internal Medicine, Kobe University Hospita

• Irino Yasuhiro

  Division of Evidence-based Laboratory Medicine, Kobe University Graduate School of Medicine

• Nagao Manabu

  Division of Cardiovascular Medicine, Kobe University Graduate School of Medicine

• Hara Tetsuya

  Division of Cardiovascular Medicine, Kobe University Graduate School of Medicine

• Otake Hiromasa

  Division of Cardiovascular Medicine, Kobe University Graduate School of Medicine

• Ishida Tatsuro

  Division of Cardiovascular Medicine, Kobe University Graduate School of Medicine

• Hirata Ken-ichi

  Division of Cardiovascular Medicine, Kobe University Graduate School of Medicine Division of Evidence-based Laboratory Medicine, Kobe University Graduate School of Medicine

Abstract

Background: Trans-fatty acid (TFA) intake increases the risk of coronary artery disease (CAD). Our previous cross-sectional survey showed that middle-aged patients with CAD in Japan have elevated serum TFA. In this study, we longitudinally investigated whether elevated TFA is a risk factor in the secondary prevention of CAD for the same-age patients. Methods and Results: A total of 112 patients (age, 21–66 years) who underwent percutaneous coronary intervention were followed up for up to 2 years. Serum elaidic acid was measured using gas chromatography/mass spectrometry as a marker of TFA intake and divided into quartiles. The primary endpoint was ischemia-driven target lesion revascularization (TLR). The hazard ratio (HR) for TLR increased significantly with higher serum elaidic acid (P<0.01). The significant positive trend remained unchanged after adjusting for conventional lipid profile and bare-metal stent usage. In contrast, although triglycerides and low-density lipoprotein cholesterol were positively correlated with elaidic acid, they were not associated with TLR. On multivariable Cox proportional hazard analysis, elevated elaidic acid was independently associated with TLR risk after adjusting for conventional coronary risks (HR, 10.7, P<0.01). Conclusions: Elevated elaidic acid is associated with higher TLR rate in middle-aged patients with CAD, suggesting that excessive TFA intake is becoming a serious health problem in Japan.

Journal

• Circulation Journal

  Circulation Journal 83 (5), 1032-1038, 2019-04-25

  The Japanese Circulation Society

Keywords

• Coronary artery disease
• Elaidic acid
• Target lesion revascularization
• Trans-fatty acid

Details

• CRID: 1390282763110287616
• NII Article ID: 130007636975
• NII Book ID: AA11591968
• DOI: 10.1253/circj.cj-18-1175
• ISSN: 13474820
• ISSN: 13469843
• HANDLE: 20.500.14094/90007319
• NDL BIB ID: 029661355
• PubMed: 30867359
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I029661355
• Web Site: https://www.jstage.jst.go.jp/article/circj/83/5/83_CJ-18-1175/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2020029153
• Text Lang: en
• Data Source:
  • JaLC
  • IRDB
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed