Target of Triglycerides as Residual Risk for Cardiovascular Events in Patients With Coronary Artery Disease　― Post Hoc Analysis of the FMD-J Study A ―

• Kajikawa Masato

  Division of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University Hospital

• Maruhashi Tatsuya

  Department of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University

• Kishimoto Shinji

  Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University

• Matsui Shogo

  Department of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University

• Hashimoto Haruki

  Department of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University

• Takaeko Yuji

  Department of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University

• Yusoff Farina Mohamad

  Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University

• Kihara Yasuki

  Department of Cardiovascular Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University

• Chayama Kazuaki

  Department of Gastroenterology and Metabolism, Institute of Biomedical and Health Sciences, Graduate School of Biomedical and Health Sciences, Hiroshima University

• Goto Chikara

  Department of Physical Therapy, Hiroshima International University

• Noma Kensuke

  Division of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University Hospital Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University

• Nakashima Ayumu

  Division of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University Hospital

• Tomiyama Hirofumi

  Department of Cardiology, Tokyo Medical University

• Takase Bonpei

  Division of Biomedical Engineering, National Defense Medical College Research Institute

• Kohro Takahide

  Department of Clinical Informatics, Jichi Medical University School of Medicine

• Suzuki Toru

  Cardiovascular Medicine, University of Leicester

• Ishizu Tomoko

  Cardiovascular Division, Institute of Clinical Medicine, University of Tsukuba

• Ueda Shinichiro

  Department of Clinical Pharmacology and Therapeutics, University of the Ryukyu School of Medicine

• Yamazaki Tsutomu

  Department of Clinical Epidemiology and Systems, Faculty of Medicine, The University of Tokyo

• Furumoto Tomoo

  Department of Cardiovascular Medicine, Hokkaido University Graduate School of Medicine

• Kario Kazuomi

  Division of Cardiovascular Medicine, Jichi Medical University School of Medicine

• Inoue Teruo

  Department of Cardiovascular Medicine, Dokkyo Medical University

• Koba Shinji

  Department of Medicine, Division of Cardiology, Showa University School of Medicine

• Watanabe Kentaro

  Department of Neurology, Hematology, Metabolism, Endocrinology and Diabetology (DNHMED), Yamagata University School of Medicine

• Takemoto Yasuhiko

  Department of Internal Medicine and Cardiology, Osaka City University Graduate School of Medicine

• Hano Takuzo

  Department of Medical Education and Population-based Medicine, Postgraduate School of Medicine, Wakayama Medical University

• Sata Masataka

  Department of Cardiovascular Medicine, Institute of Health Biosciences, The University of Tokushima Graduate School

• Ishibashi Yutaka

  Department of General Medicine, Shimane University Faculty of Medicine

• Node Koichi

  Department of Cardiovascular and Renal Medicine, Saga University

• Maemura Koji

  Department of Cardiovascular Medicine, Course of Medical and Dental Sciences, Graduate School of Biomedical Sciences, Nagasaki University

• Ohya Yusuke

  The Third Department of Internal Medicine, University of the Ryukyus

• Furukawa Taiji

  Department of Internal Medicine, Teikyo University School of Medicine

• Ito Hiroshi

  Department of Cardiovascular Medicine, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences

• Ikeda Hisao

  Faculty of Fukuoka Medical Technology, Teikyo University

• Yamashina Akira

  Department of Cardiology, Tokyo Medical University

• Higashi Yukihito

  Division of Regeneration and Medicine, Medical Center for Translational and Clinical Research, Hiroshima University Hospital Department of Cardiovascular Regeneration and Medicine, Research Institute for Radiation Biology and Medicine, Hiroshima University

Abstract

Background: Circulating triglyceride (TG) levels are a current focus as a residual risk for cardiovascular (CV) events. We evaluated the relationship between circulating TG levels and future CV events in patients with coronary artery disease (CAD) who were treated with conventional therapy. Methods and Results: We analyzed data for 652 patients who were enrolled in the FMD-J Study A. We investigated the associations between serum TG levels and first major CV events (death from CV cause, nonfatal acute coronary syndrome (ACS), nonfatal stroke, and CAD) for a 3-year follow-up period. Patients were divided into 4 groups based on serum TG level: low-normal (<100 mg/dL), high-normal (100–149 mg/dL), borderline hypertriglyceridemia (150–199 mg/dL), and moderate hypertriglyceridemia (≥200 mg/dL). During a median follow-up period of 46.6 months, 14 patients died (9 from CV causes), 16 had nonfatal ACS, 6 had nonfatal stroke, and 54 had CAD. The Kaplan-Meier curves for first major CV event among the 4 groups were significantly different (P=0.04). After adjustment for various confounders, serum TG level ≥100 mg/dL were significantly associated with an increased risk of first major CV events compared with serum TG level <100 mg/dL. Conclusions: Serum TG level may be a surrogate marker for predicting CV events in patients with CAD.

Journal

• Circulation Journal

  Circulation Journal 83 (5), 1064-1071, 2019-04-25

  The Japanese Circulation Society

Keywords

• Atherosclerosis
• Cardiovascular events
• Triglycerides

Details

• CRID: 1390564238087338496
• NII Article ID: 130007636980
• NII Book ID: AA11591968
• DOI: 10.1253/circj.cj-18-1082
• ISSN: 13474820
• ISSN: 13469843
• NDL BIB ID: 029661386
• PubMed: 30918221
• Web Site: https://repo.lib.tokushima-u.ac.jp/114197
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I029661386
• Web Site: https://www.jstage.jst.go.jp/article/circj/83/5/83_CJ-18-1082/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2020029157
• Text Lang: en
• Data Source:
  • JaLC
  • IRDB
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed