Specified Kiwifruit Extract Blocks Increase of Body Weight and Visceral Fat in High-fat-diet-fed Mice by Inhibiting Intestinal Lipase

DOI Web Site 被引用文献1件 参考文献20件
  • Iwata Satomi
    Research and Development, Omnica Co., Ltd.
  • Kato Takako
    Laboratory of Biopharmaceutics, Faculty of Pharmacy, Takasaki University of Health and Welfare
  • Yokoyama Akari
    Laboratory of Biopharmaceutics, Faculty of Pharmacy, Takasaki University of Health and Welfare
  • Hirota Junko
    Research and Development, Omnica Co., Ltd.
  • Ogihara Takuo
    Laboratory of Biopharmaceutics, Faculty of Pharmacy, Takasaki University of Health and Welfare Laboratory of Clinical Pharmacokinetics, Graduate School of Pharmaceutical Sciences, Takasaki University of Health and Welfare

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<p>Oligomeric polyphenol-enriched specified kiwifruit extract (SKE) is reported to inhibit pancreatic lipase activity in vitro. Therefore, in this work, we investigated the effects of SKE on body weight, visceral fat, and lipid metabolism in mice fed a high-fat diet for 6 weeks. Body weight gain was significantly and dose-dependently suppressed in the groups fed a high-fat diet containing SKE (HF + SKE groups) compared to the high-fat diet control group (HF group). Moreover, Dose-dependent increases in triglyceride (TG) content in feces were observed in the HF + SKE groups. Since we confirmed that SKE inhibits lipase in vitro, these findings indicate that SKE suppresses the hydrolysis of TG by inhibiting lipase activity in the intestinal tract, thereby restricting the absorption of lipids, increasing the excretion of TG in feces, and suppressing the increase in body weight and visceral fat caused by the high-fat diet.</p>

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