Genetic differences between C57BL/6 substrains affect the process of testis differentiation in Y^POS mice

• YOKOYAMA Toshifumi

  Department of Animal Science, Graduate School of Agricultural Science, Kobe University, 1-1 Rokkodai, Nada-ku, Kobe, Hyogo 657-8501, Japan

• MIURA Yuuka

  Department of Animal Science, Graduate School of Agricultural Science, Kobe University, 1-1 Rokkodai, Nada-ku, Kobe, Hyogo 657-8501, Japan

• YAMAMOTO Anzu

  Department of Animal Science, Graduate School of Agricultural Science, Kobe University, 1-1 Rokkodai, Nada-ku, Kobe, Hyogo 657-8501, Japan

• HASEGAWA Chinatsu

  Department of Animal Science, Graduate School of Agricultural Science, Kobe University, 1-1 Rokkodai, Nada-ku, Kobe, Hyogo 657-8501, Japan

• KAWANISHI Kohei

  Department of Animal Science, Graduate School of Agricultural Science, Kobe University, 1-1 Rokkodai, Nada-ku, Kobe, Hyogo 657-8501, Japan

• TAKADA Nanako

  Department of Animal Science, Graduate School of Agricultural Science, Kobe University, 1-1 Rokkodai, Nada-ku, Kobe, Hyogo 657-8501, Japan

• OMOTEHARA Takuya

  Department of Anatomy, Tokyo Medical University, 6-1-1 Shinjuku, Shinjuku-ku, Tokyo 160-8402, Japan

• HIRANO Tetsushi

  Division of Drug and Structural Research, Life Science Research Center, University of Toyama, 2630 Sugitani, Toyama 930-0194, Japan

• MANTANI Yohei

  Department of Animal Science, Graduate School of Agricultural Science, Kobe University, 1-1 Rokkodai, Nada-ku, Kobe, Hyogo 657-8501, Japan

• MIKI Takanori

  Departments of Anatomy and Neurobiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kagawa 761-0793, Japan

• HOSHI Nobuhiko

  Department of Animal Science, Graduate School of Agricultural Science, Kobe University, 1-1 Rokkodai, Nada-ku, Kobe, Hyogo 657-8501, Japan

Abstract

C57BL/6J-XY^POS (B6J-XY^POS) mice, which have the Y chromosome derived from Mus musculus poschiavinus on a B6J genetic background, form ovotestes or ovaries. Previously, we replaced the genetic background of B6J-XY^POS mice with B6N and found that individuals with testes also appeared in addition to those with ovaries or ovotestes. To investigate the effect of the B6J genetic sequence on the testis differentiation, the genetic background of B6N-XY^POS mice was replaced with B6J again. The recovery of the B6J genetic background significantly decreased the incidence of testes; only ovaries developed. These results indicate that the testicular differentiation process tends to be perturbed especially in the B6J substrain. This shows the importance of substrain differences in mice usually treated as B6 collectively.

Journal

• Journal of Veterinary Medical Science

  Journal of Veterinary Medical Science 81 (4), 608-611, 2019

  JAPANESE SOCIETY OF VETERINARY SCIENCE

Keywords

• C57BL/6
• <i>Mus musculus poschiavinus</i>
• sex reversal
• substrain
• testis differentiation

Details

• CRID: 1390282763111214464
• NII Article ID: 130007638718
• DOI: 10.1292/jvms.18-0621
• ISSN: 13477439
• ISSN: 09167250
• HANDLE: 20.500.14094/90005964
• PubMed: 30828038
• Web Site: https://www.jstage.jst.go.jp/article/jvms/81/4/81_18-0621/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2019360227
• Text Lang: en
• Data Source:
  • JaLC
  • IRDB
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed