Blueberry Leaf Polyphenols Prevent Body Fat Accumulation in Mice Fed High-fat, High-sucrose Diet

• Fujii Kento

  Department of Biochemistry and Applied Biosciences, Faculty of Agriculture, University of Miyazaki

• Ota Yuma

  Department of Biochemistry and Applied Biosciences, Faculty of Agriculture, University of Miyazaki

• Nishiyama Kazuo

  Department of Biochemistry and Applied Biosciences, Faculty of Agriculture, University of Miyazaki

• Kunitake Hisato

  Department of Biochemistry and Applied Biosciences, Faculty of Agriculture, University of Miyazaki

• Yamasaki Yumi

  Faculty of Regional Innovation, University of Miyazaki

• Tari Hiroyuki

  Bizen Chemical Company Limited

• Araki Kaori

  Bizen Chemical Company Limited

• Arakawa Teruaki

  Bizen Chemical Company Limited

• Yamasaki Masao

  Department of Biochemistry and Applied Biosciences, Faculty of Agriculture, University of Miyazaki

Bibliographic Information

Other Title

• Blueberry leaf polyphenols prevent body fat accumulation in mice fed high-fat

Abstract

Blueberry leaf is currently a popular dietary supplement. Effects of dietary blueberry leaf and its active components on body fat accumulation were examined. C57BL/6J mice were fed high-fat, high-sucrose diet with or without 3% blueberry leaf extract (BLEx) or 3% concentrated-polyphenolic BLEx (CP BLEx) for 8 weeks. Compared to mice fed a high-fat, high-sucrose diet without blueberry leaf, BLEx and CP BLEx significantly reduced body weight and adipose tissue weight gain. Adipocytes were also smaller and and liver lipid accumulatioin was significantly inhibited in mice fed either BLEx or CP BLEx. These effects tended to be more pronounced in mice fed CP BLEx compared to in mice fed BLEx. Together, results suggest that blueberry leaf inhibits body fat accumulation typically observed in mice fed a high-fat, high-sucrose diet, and that inhibition is attributable to polyphenolic components in leaf extracts.

Journal

• Journal of Oleo Science

  Journal of Oleo Science 68 (5), 471-479, 2019

  Japan Oil Chemists' Society

Keywords

• blueberry leaf
• polyphenol
• chlorogenic acid
• proanthocyanidin
• obesity

Details

• CRID: 1390001288135442048
• NII Article ID: 130007641008
• NII Book ID: AA11503337
• DOI: 10.5650/jos.ess18226
• ISSN: 13473352
• ISSN: 13458957
• NDL BIB ID: 029661066
• PubMed: 30971641
• Web Site: http://id.ndl.go.jp/bib/029661066
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I029661066
• Web Site: https://www.jstage.jst.go.jp/article/jos/68/5/68_ess18226/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2020029137
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed