Capabilities of fecal calprotectin and blood biomarkers as surrogate endoscopic markers according to ulcerative colitis disease type
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- Sonoyama Hiroki
- Department of Internal Medicine II, Shimane University Hospital
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- Kawashima Kousaku
- Department of Internal Medicine II, Shimane University Hospital Inflammatory Bowel Disease Center, Shimane University Hospital
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- Ishihara Shunji
- Department of Internal Medicine II, Shimane University Hospital Inflammatory Bowel Disease Center, Shimane University Hospital
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- Kotani Satoshi
- Department of Internal Medicine II, Shimane University Hospital
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- Fukuba Nobuhiko
- Department of Internal Medicine II, Shimane University Hospital
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- Oka Akihiko
- Department of Internal Medicine II, Shimane University Hospital
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- Kusunoki Ryusaku
- Department of Internal Medicine II, Shimane University Hospital
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- Tada Yasumasa
- Department of Internal Medicine II, Shimane University Hospital
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- Mishima Yoshiyuki
- Department of Internal Medicine II, Shimane University Hospital
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- Oshima Naoki
- Department of Internal Medicine II, Shimane University Hospital
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- Moriyama Ichiro
- Department of Internal Medicine II, Shimane University Hospital Cancer Center, Shimane University Hospital
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- Yuki Takafumi
- Department of Internal Medicine II, Shimane University Hospital
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- Onishi Koji
- Division of Internal Medicine, Matsue Seikyo General Hospital
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- Kinoshita Yoshikazu
- Department of Internal Medicine II, Shimane University Hospital
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<p>Fecal calprotectin level in ulcerative colitis patients is correlated with endoscopic findings. However, its association with various ulcerative colitis disease types has not been elucidated. In the present study, we investigated the correlation of fecal calprotectin level with endoscopic findings as compared to blood biomarkers according to ulcerative colitis disease type. Fecal calprotectin as well as the blood biomarkers: C-reactive protein (CRP), white blood count (WBC), erythrocyte sedimentation rate (ESR), hemoglobin, platelet count (PLT), and serum albumin (Alb) were measured in patients who underwent a complete colonoscopy. Disease type was divided into proctitis, left-sided colitis, and extensive colitis. Correlations of fecal calprotectin and blood biomarker levels with Mayo endoscopic subscore were analyzed. A total of 186 colonoscopy examinations were performed in 124 patients with ulcerative colitis. Fecal calprotectin level showed a significant correlation with Mayo endoscopic subscore regardless of disease type (proctitis, r = 0.54, p<0.01; left-sided colitis, r = 0.75, p<0.01; extensive colitis, r = 0.78, p<0.01), and clearly discriminated inactive (Mayo endoscopic subscore 0) from active stages (Mayo endoscopic subscore 1–3). On the other hand, none of the examined blood biomarkers showed a correlation with Mayo endoscopic subscore in the proctitis group, while weak correlations of several biomarkers (CRP, WBC, ESR, PLT and Alb) with Mayo endoscopic subscore were found in left-sided colitis and extensive colitis cases. This is the first report to elucidate the capabilities of fecal calprotectin and blood biomarkers as endoscopic surrogate markers according to ulcerative colitis disease type.</p>
収録刊行物
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- Ｊｏｕｒｎａｌ ｏｆ Ｃｌｉｎｉｃａｌ Ｂｉｏｃｈｅｍｉｓｔｒｙ ａｎｄ Ｎｕｔｒｉｔｉｏｎ
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Ｊｏｕｒｎａｌ ｏｆ Ｃｌｉｎｉｃａｌ Ｂｉｏｃｈｅｍｉｓｔｒｙ ａｎｄ Ｎｕｔｒｉｔｉｏｎ 64 (3), 265-270, 2019
一般社団法人 日本酸化ストレス学会
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詳細情報 詳細情報について
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- CRID
- 1390282763112187136
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- NII論文ID
- 130007641427
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- ISSN
- 18805086
- 09120009
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- 本文言語コード
- en
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- データソース種別
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- JaLC
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- CiNii Articles
- KAKEN
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