Inhibition Mechanisms of Hepatitis C Virus Infection by Caffeic Acid and Tannic Acid

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Author(s)

Abstract

<p>Previously, we reported that coffee extract and its constituents, caffeic acid (CA) and <i>p</i>-coumaric acid, inhibit infection by the hepatitis C virus (HCV). In the present report, we identified another coffee-related compound, tannic acid (TA), which also inhibits HCV infection. We systematically evaluated which steps of the viral lifecycle were affected by CA and TA. TA substantially inhibits HCV RNA replication and egression, while CA does not. The infectivity of the HCV pretreated with CA or TA was almost lost. Cellular attachment of HCV particles and their interaction with apolipoprotein E, which is essential for HCV infectivity, were significantly reduced by CA. These results indicate that CA inhibits HCV entry <i>via</i> its direct effect on viral particles and TA inhibits HCV RNA replication and particle egression as well as entry into host cells. Taken together, our findings may provide insights into CA and TA as potential anti-HCV strategies.</p>

Journal

  • Biological and Pharmaceutical Bulletin

    Biological and Pharmaceutical Bulletin 42(5), 770-777, 2019

    The Pharmaceutical Society of Japan

Codes

  • NII Article ID (NAID)
    130007641446
  • NII NACSIS-CAT ID (NCID)
    AA10885497
  • Text Lang
    ENG
  • ISSN
    0918-6158
  • NDL Article ID
    029657765
  • NDL Call No.
    Z53-V41
  • Data Source
    NDL  J-STAGE 
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