The Reparative Effect of Dendrobium officinale Protocorms against Photodamage Caused by UV-Irradiation in Hairless Mice
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- Mai Yansui
- Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine
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- Niu Zheng
- Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine
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- He Wenda
- Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine
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- Lai Xiaoping
- Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine
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- Huang Song
- Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine
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- Zheng Xiasheng
- Mathematical Engineering Academy of Chinese Medicine, Guangzhou University of Chinese Medicine
書誌事項
- タイトル別名
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- The Reparative Effect of <i>Dendrobium officinale</i> Protocorms against Photodamage Caused by UV-Irradiation in Hairless Mice
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<p>Dendrobium officinale protocorms (DOPs) are a specific developmental stage of Dendrobium officinale KIMURA et MIGO, which is used in folk medicine to ease skin issues, such as wrinkles and erythema. The purpose of the current study was to evaluate the effect of DOPs on UV irradiation-induced skin damage in bc_nu hairless mice, using matrixyl as a positive control. Hairless mice were randomly separated into 6 groups (8 mice per group). The normal control group received solvent and was not exposed to UV irradiation, while the model control group received solvent and was exposed to UV irradiation. The positive control group was subjected to UV irradiation and then received a 10 mg/mL formulation of matrixyl. The DOPs-treated groups received a transdermal application of a DOPs formulation after 4 weeks of UV irradiation. Relevant indicators, such as catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), thiobarbituric acid reactive substances (TBARS) and matrix metalloproteinases (MMPs), were then used to evaluate the ability of DOPs to repair photodamage. The results indicated that DOPs significantly reduced erythema and protected the skin from dryness and therefore exhibits a significant anti-photoaging effect. In addition, the expression of CAT, SOD, and GSH-Px increased while TBARS and MMPs levels decreased in DOPs-treated mice. This demonstrated that DOPs can inhibit photodamage in the skin of hairless mice. DOPs could be used as a potential therapeutic agent to protect the skin against UV-induced photoaging.</p>
収録刊行物
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- Biological & Pharmaceutical Bulletin
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Biological & Pharmaceutical Bulletin 42 (5), 728-735, 2019-05-01
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390282763112021632
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- NII論文ID
- 130007641458
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- NII書誌ID
- AA10885497
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- ISSN
- 13475215
- 09186158
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- NDL書誌ID
- 029657714
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- PubMed
- 31061314
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可