Maternal Immune Activation in Pregnant Mice Produces Offspring with Altered Hippocampal Ripples

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Author(s)

    • Ikegaya Yuji Ikegaya Yuji
    • Graduate School of Pharmaceutical Sciences, The University of Tokyo|Center for Information and Neural Networks, National Institute of Information and Communications Technology

Abstract

<p>Psychiatric disorders, such as schizophrenia and autism spectrum disorder, are associated with sleep disturbances and deficits in memory consolidation; however, the relationship between these symptoms remains unclear. Here, we focused on hippocampal sharp-wave ripples (SWRs), a form of transient high-frequency oscillations that occur during sleep and behavioral immobility and contribute to memory consolidation. We activated the maternal immune system with polyinosinic–polycytidylic acid (poly(I : C)), one of the major pharmacological models of psychiatric disorders, to investigate whether SWR activity is altered in acute slices of the hippocampus from offspring born to poly(I : C)-treated mouse dams. Using robust continuous clustering in a low dimensional space defined by a uniform manifold approximation and projection, we found that mice with prenatal exposure to poly(I : C) exhibited different feature distributions of SWR waveforms without affecting the overall frequencies of SWR events. Based on our results, maternal immune activation leads to altered SWR patterns in offspring.</p>

Journal

  • Biological and Pharmaceutical Bulletin

    Biological and Pharmaceutical Bulletin 42(5), 666-670, 2019

    The Pharmaceutical Society of Japan

Codes

  • NII Article ID (NAID)
    130007641486
  • NII NACSIS-CAT ID (NCID)
    AA10885497
  • Text Lang
    ENG
  • ISSN
    0918-6158
  • NDL Article ID
    029657639
  • NDL Call No.
    Z53-V41
  • Data Source
    NDL  J-STAGE 
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