Synaptic functions and their disruption in schizophrenia: From clinical evidence to synaptic optogenetics in an animal model
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- OBI-NAGATA Kisho
- Laboratory of Medical Neuroscience, Institute for Molecular and Cellular Regulation, Gunma University
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- TEMMA Yusuke
- Laboratory of Medical Neuroscience, Institute for Molecular and Cellular Regulation, Gunma University
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- HAYASHI-TAKAGI Akiko
- Laboratory of Medical Neuroscience, Institute for Molecular and Cellular Regulation, Gunma University PRESTO, Japan Science and Technology Agency
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<p>The adult human brain consists of approximately a hundred billion neurons, which are connected via synapses. The pattern and strength of the synaptic connections are constantly changing (synaptic plasticity), and these changes are considered to underlie learning, memory, and personality. Many psychiatric disorders have been related to disturbances in synaptogenesis and subsequent plasticity. In this review, we summarize findings of synaptic disturbance and its involvement in the pathogenesis and/or pathophysiology of psychiatric disorders. We will focus on schizophrenia, because this condition has a high proven heritability, which offers more unambiguous insights into the biological origins of not only schizophrenia but also related psychiatric disorders. To demonstrate the involvement of synaptopathy in psychiatric disorders, we discuss what knowledge is missing at the circuits level, and what new technologies are needed to achieve a comprehensive understanding of synaptopathy in psychiatric disorders.</p>
収録刊行物
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- Proceedings of the Japan Academy. Ser. B: Physical and Biological Sciences
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Proceedings of the Japan Academy. Ser. B: Physical and Biological Sciences 95 (5), 179-197, 2019-05-10
日本学士院
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詳細情報 詳細情報について
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- CRID
- 1390845713065693568
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- NII論文ID
- 130007643986
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- NII書誌ID
- AA00785485
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- ISSN
- 13492896
- 03862208
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- NDL書誌ID
- 029700683
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- PubMed
- 31080187
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可