Daucosterol induces autophagic-dependent apoptosis in prostate cancer <i>via</i> JNK activation
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- Gao Ping
- Department of Urology, Hospital of Chengdu University of Traditional Chinese Medicine Department of Andrology, Hospital of Chengdu University of Traditional Chinese Medicine
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- Huang Xiaopeng
- Department of Andrology, Hospital of Chengdu University of Traditional Chinese Medicine
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- Liao Tingting
- Department of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine
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- Li Guangsen
- Department of Andrology, Hospital of Chengdu University of Traditional Chinese Medicine
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- Yu Xujun
- Medicine and Life Sciences College, Chengdu University of Traditional Chinese Medicine
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- You Yaodong
- Department of Andrology, Hospital of Chengdu University of Traditional Chinese Medicine
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- Huang Yuxing
- Department of Neurosurgery, Hospital of Chengdu University of Traditional Chinese Medicine
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抄録
<p>Plant sterols (phytosterols) have been widely accepted as a natural anti-cancer agent in multiple malignant tumors. This study was designed to investigate the functions of daucosterol in prostate cancer progression and its possible molecular mechanisms. Our results showed that daucosterol inhibited cell proliferation and induced cell cycle arrest. Moreover, daucosterol treatment obviously promoted apoptosis and autophagy. An autophagy inhibitor, 3-methyladenine (3-MA) was proved to counteract daucosterol-triggered autophagy, growth inhibition, and apoptosis, indicating that daucosterol-induced apoptotic response was dependent on autophagy. Additionally, treatment with daucosterol resulted in increased phosphorylation of c-Jun N-terminal kinase (JNK). Furthermore, pre-treatment with a JNK-specific inhibitor SP600125 abated daucosterol-elicited autophagy and apoptotic cell death. Taken together, our findings demonstrated that daucosterol blocked prostate cancer growth at least partly through inducing autophagic-dependent apoptosis via activating JNK signaling, providing a promising candidate for the development of antitumor drugs in prostate cancer treatment.</p>
収録刊行物
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- BioScience Trends
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BioScience Trends 13 (2), 160-167, 2019-04-30
特定非営利活動法人 バイオ＆ソーシャル・サイエンス推進国際研究交流会