Physiological centers of decision-making: manipulation of neural activity in insular cortex by AAV

DOI Web Site Web Site PubMed 33 References
  • Mizoguchi Hiroyuki
    Research Center for Next-Generation Drug Development, Research Institute of Environmental Medicine, Nagoya University
  • Yamada Kiyofumi
    Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine

Bibliographic Information

Other Title
  • はまる脳，リスク志向な脳：ウイルスベクターによる島皮質機能操作
  • ハマル ノウ,リスク シコウ ナ ノウ : ウイルスベクター ニ ヨル シマ ヒシツ キノウ ソウサ

Search this article

Abstract

<p>Decision-making is a key activity process that influences many aspects of daily living and both mental and physical health. In general, healthy participants reveal rational choice, but patients with neuropsychiatric disorders reveal irrational and risky choice in decision-making. Addiction is one of typical diseases revealed risky decision-making, addicts select risky action and options that confer short-term rewards at the cost of long-term disadvantages. Thus, irrational and risky decision-making is recognized as a core problem in patients with neuropsychiatric disorders, and a better understanding of the mechanisms underlying altered decision-making would provide insights into potential therapeutic approaches for these diseases. However, the neural pathway and substrates underlying these deficits are particularly unknown. Recently, we found that insular cortex is one of key regions for risky decision-making in an animal model of methamphetamine addiction, by using the designer receptor exclusively activated by designer drug (DREADD) technology, and that GABAergic dysfunction in insular cortex is involved in evaluating the subjective value of reward and reward prediction error. These brain dysfunctions would be related to risk taking behavior in addiction. In this review, we introduced the possible neural pathway related to risky decision-making and behavioral changes in choice strategy using adeno associated virus (AAV).</p>

Journal

References(33)*help

See more

Related Projects

See more

Keywords

Details 詳細情報について

Report a problem

Back to top