Incidence of acute hepatitis B in a metropolitan area: a follow-up study after increased genotype A infection

DOI Web Site Web Site 23 References
  • Yamada Norie
    Department of Internal Medicine, Center for Liver Diseases, Seizankai Kiyokawa Hospital Department of Virology II, National Institute of Infectious Diseases
  • Hiraishi Tetsuya
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kawasaki Municipal Tama Hospital
  • Kobayashi Minoru
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine
  • Ikeda Hiroki
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine
  • Watanabe Tsunamasa
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, St. Marianna University School of Medicine
  • Okuse Chiaki
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kawasaki Municipal Tama Hospital
  • Imai Yasuharu
    AMS Palace Building Clinic
  • Yotsuyanagi Hiroshi
    Division of Infectious Diseases, Advanced Clinical Research Center, The Institute of Medical Science, The University of Tokyo
  • Kato Takanobu
    Department of Virology II, National Institute of Infectious Diseases
  • Suzuki Michihiro
    Division of Gastroenterology and Hepatology, Department of Internal Medicine, Kawasaki Municipal Tama Hospital
  • Yasuda Kiyomi
    Department of Internal Medicine, Center for Liver Diseases, Seizankai Kiyokawa Hospital

Bibliographic Information

Other Title
  • 首都圏におけるB型急性肝炎の変遷：―Genotype Aの急増から10年を経て―
  • シュトケン ニ オケル Bガタ キュウセイ カンエン ノ ヘンセン : Genotype A ノ キュウゾウ カラ 10ネン オ ヘテ

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Abstract

<p>We investigated the incidence of acute hepatitis B (AH-B) infection in the metropolitan area from 1994 to 2017. A total of 246 AH-B cases were recorded. The number of patients with AH-B increased between 1994 and 2004 but decreased after 2010. After initiating the observation period, the incidence of infections with genotype (GT) A gradually increased and accounted for most cases after 2006. Infections were also observed in young men; moreover, sexual transmission was frequently observed. Among 166 patients who were continuously observed, 5 developed chronic infections (GTA, 3 patients; GTC, 1 patient; and GTH, 1 patient). The evaluation of amino acid polymorphisms in the a-determinant region revealed that seven patients had amino acid substitutions. Continuous monitoring of the incidence and characterization of AH-B is required, and education regarding the importance of HB vaccination is necessary for controlling this viral infection.</p>

Journal

  • Kanzo

    Kanzo 60 (5), 139-146, 2019-05-01

    The Japan Society of Hepatology

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