Impaired Flow-Mediated Dilation and Severity and Vulnerability of Culprit Plaque in Patients with Coronary Artery Disease
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- Nemoto Teruyoshi
- Kitasato University Graduate School of Medical Sciences
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- Minami Yoshiyasu
- Department of Cardiovascular Medicine, Kitasato University School of Medicine
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- Yamaoka-Tojo Minako
- Department of Rehabilitation, Kitasato University School of Allied Health Sciences
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- Sato Toshimitsu
- Kitasato University Graduate School of Medical Sciences
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- Muramatsu Yusuke
- Kitasato University Graduate School of Medical Sciences
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- Kakizaki Ryota
- Kitasato University Graduate School of Medical Sciences
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- Fujiyoshi Kazuhiro
- Kitasato University Graduate School of Medical Sciences
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- Hashimoto Takuya
- Kitasato University Graduate School of Medical Sciences
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- Meguro Kentaro
- Department of Cardiovascular Medicine, Kitasato University School of Medicine
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- Shimohama Takao
- Department of Cardiovascular Medicine, Kitasato University School of Medicine
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- Tojo Taiki
- Department of Cardiovascular Medicine, Kitasato University School of Medicine
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- Ako Junya
- Department of Cardiovascular Medicine, Kitasato University School of Medicine
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抄録
<p>The association between endothelial function, evaluated using flow-mediated dilatation (FMD), and the severity of coronary artery disease remains to be elucidated.</p><p>A total of 245 consecutive patients with stable angina were prospectively enrolled. FMD was evaluated in the brachial artery before percutaneous coronary intervention. Patients were divided into 2 groups according to the FMD value (lower FMD group [FMD < 2.0], n = 82; higher FMD group [FMD ≥ 2.0], n = 163). The severity of coronary artery disease was evaluated using findings of angiography and optical coherence tomography, and compared between the 2 groups.</p><p>The prevalence of left main (LM) disease was significantly higher in the lower FMD group than in the higher FMD group (8.5% versus 2.5%, P = 0.046), although the prevalence of multivessel disease was comparable between the groups. Lower FMD was independently associated with a higher prevalence of LM disease (odds ratio, 3.89; 95% confidence interval, 1.12-15.5; P = 0.033). A general linear model with multiple variables revealed that the minimal lumen area (MLA) in the culprit lesion was significantly smaller in patients with lower FMD than in those with higher FMD (regression coefficient b, −0.249 mm2; 95% confidence interval, −0.479-−0.018 mm2; P = 0.035). The prevalence ofvulnerable plaque characteristics was comparable between the 2 groups.</p><p>Patients with lower FMD had a higher incidence of LM disease and a smaller MLA in the culprit lesion. FMD may be a useful, noninvasive indicator for identifying patients with severe coronary artery disease.</p>
収録刊行物
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- International Heart Journal
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International Heart Journal 60 (3), 539-545, 2019-05-30
一般社団法人 インターナショナル・ハート・ジャーナル刊行会