Ameliorative Effect of High-Dose Vitamin C Administration on Dextran Sulfate Sodium-Induced Colitis Mouse Model

• Kondo Kanako

  Department of Pharmaceutical Science, Suzuka University of Medical Science Department of Pharmacy, Kuwana City Medical Center

• Hiramoto Keiichi

  Department of Pharmaceutical Science, Suzuka University of Medical Science

• Yamate Yurika

  Department of Pharmaceutical Science, Suzuka University of Medical Science

• Goto Kenji

  Department of Pharmaceutical Science, Suzuka University of Medical Science

• Sekijima Hidehisa

  Department of Pharmaceutical Science, Suzuka University of Medical Science

• Ooi Kazuya

  Department of Pharmaceutical Science, Suzuka University of Medical Science

抄録

Vitamin C is a natural nutrient with antioxidant properties and is used as a health supplement. In this study, we examined the effects of intraperitoneal administration of high-dose vitamin C (4 g/kg) on dextran sodium sulfate (DSS)-induced ulcerative colitis. We prepared a mouse ulcerative colitis model by administering DSS for 7 d along with high-dose vitamin C each day during DSS treatment. Ulcerative colitis induced by DSS was ameliorated by high-dose vitamin C administration. Blood levels of interleukin-6, tumor necrosis factor-α, hydrogen peroxide (H₂O₂), and iron were elevated in DSS-treated mice but lowered by high-dose vitamin C administration. Contrarily, the levels of H₂O₂ and iron and the numbers of terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling (TUNEL)-positive cells in the colon were further increased by high-dose vitamin C administration. The expression levels of fibroblasts, collagen type I, and collagen type III decreased in the DSS-treated mice but increased in mice administered high-dose vitamin C. These results suggest that high-dose vitamin C administration can improve ulcerative colitis.

収録刊行物

• Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ

  Ｂｉｏｌｏｇｉｃａｌ　＆　Ｐｈａｒｍａｃｅｕｔｉｃａｌ　Ｂｕｌｌｅｔｉｎ 42 (6), 954-959, 2019-06-01

  公益社団法人 日本薬学会

キーワード

• apoptosis
• collagen type I
• collagen type III
• dextran sodium sulfate-induced ulcerative colitis
• hydrogen peroxide
• vitamin C

詳細情報

• CRID: 1390282763118972672
• NII論文ID: 130007657681
• NII書誌ID: AA10885497
• DOI: 10.1248/bpb.b18-00967
• ISSN: 13475215
• ISSN: 09186158
• NDL書誌ID: 029698509
• PubMed: 31155592
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I029698509
• Web Site: https://www.jstage.jst.go.jp/article/bpb/42/6/42_b18-00967/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2020048932
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可