細菌III 型分泌装置による細胞膜を越えたタンパク質輸送

• 扇田 隆司

  京都薬科大学薬品物理化学分野

書誌事項

タイトル別名

• Protein Transport across the Bio–membranes by Bacterial Type III Secretion System
• サイキン Ⅲ カタ ブンピ ソウチ ニ ヨル サイボウマク オ コエタ タンパクシツ ユソウ

抄録

Pathogenic bacteria deliver effector proteins directly into host cells via type III secretion system (T3SS) to prime the host cell environment for infection. Thus T3SS inhibitor would potently suppress bacterial infection. For molecular design of T3SS inhibitor, clarification of the protein transport mechanism of T3SS is required. We previously demonstrated that T3SS needle rotates by proton–motive force (PMF) and effector transport of T3SS is suppressed by inhibition of needle rotation. In this review, we summarize the recent knowledge about effector transport of T3SS and introduce our novel model of effector transport mechanism of T3SS based on our findings.

収録刊行物

• 膜

  膜 44 (3), 101-104, 2019

  日本膜学会

キーワード

• type Ⅲ secretion system
• protein export
• bacterial infection
• rotary motor

詳細情報

• CRID: 1390845713075807744
• NII論文ID: 130007661135
• NII書誌ID: AN0023215X
• DOI: 10.5360/membrane.44.101
• ISSN: 18846440
• ISSN: 03851036
• NDL書誌ID: 030039247
• Web Site: http://id.ndl.go.jp/bib/030039247
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I030039247
• Web Site: https://www.jstage.jst.go.jp/article/membrane/44/3/44_101/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2019295820
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN
• 抄録ライセンスフラグ: 使用不可