日本疾患モデル学会記録 Elevated maternal retinoic acid-related orphan receptor-γt enhances the effect of polyinosinic–polycytidylic acid in inducing fetal loss

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Author(s)

    • TOME Saki
    • Department of Anatomy and Neuroscience, Faculty of Medicine, University of Tsukuba|Department of Kansei, Behavioral, and Brain Science, Graduate School of Comprehensive Human Sciences, University of Tsukuba
    • SASAKI Tetsuya
    • Department of Anatomy and Neuroscience, Faculty of Medicine, University of Tsukuba|Department of Kansei, Behavioral, and Brain Science, Graduate School of Comprehensive Human Sciences, University of Tsukuba
    • TAKAHASHI Satoru
    • Department of Anatomy and Embryology, Faculty of Medicine, University of Tsukuba
    • TAKEI Yosuke
    • Department of Anatomy and Neuroscience, Faculty of Medicine, University of Tsukuba|Department of Kansei, Behavioral, and Brain Science, Graduate School of Comprehensive Human Sciences, University of Tsukuba

Abstract

<p>T helper 17 (Th17) cells have been suggested to play a crucial role in various complications during pregnancy by participating in maternal immune activation (MIA). To test a possible role for Th17 cells in MIA-mediated abortion, we analyzed transgenic mice overexpressing retinoic acid-related orphan receptor gamma-t (RORγt), a master regulator of IL-17 producing cell development. These mutant mice (RORγt Tg mice) exhibited a constitutive upregulation of serum interleukin-17A (IL-17A) and decreased E-cadherin expression in cell–cell junctions of placental tissues. Abortion after the administration of a viral-mimicking synthetic double-stranded RNA polyinosinic–polycytidylic acid was more frequent in RORγt Tg mice than wild-type mice. These results suggest that excessive Th17 cell activity alters immune responsiveness and increases the rate of abortion during gestation.</p>

Journal

  • Experimental Animals

    Experimental Animals, 2019

    Japanese Association for Laboratory Animal Science

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