Effects of food supplements on periodontal status and local and systemic inflammation after nonoperative periodontal treatment
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- Rasperini Giulio
- Department of Biomedical, Surgical and Dental Sciences, University of Milan Foundation Scientific Institute of Hospitalization and Care (IRCCS), Ca’ Granda Policlinic
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- Pellegrini Gaia
- Department of Biomedical, Surgical and Dental Sciences, University of Milan
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- Sugai Jim
- Department of Periodontics and Oral Medicine, University of Michigan School of Dentistry
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- Mauro Cesare
- Department of Biomedical, Surgical and Dental Sciences, University of Milan
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- Fiocchi Simone
- Private practice
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- Corvi Mora Paolo
- Pharma consultant
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- Dellavia Claudia
- Department of Biomedical, Surgical and Dental Sciences, University of Milan
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Abstract
<p>The present study aimed to assess the effects of a multimicronutrient food supplement on periodontal clinical parameters and systemic/local inflammatory markers. Thirty patients with severe chronic periodontitis who adhered to the Mediterranean diet (MD) underwent non-surgical therapy and daily took either the micronutrient complex (group-A) or olive oil (group-B) from baseline (T0) to 3 months (T2). Supragingival debridement was performed at T0. One month later (T1), one-stage-full-mouth disinfection was performed. Periodontal clinical parameters were monitored and correlated with serum C-reactive protein (CRP) and salivary matrix metalloproteinase-8/9 (MMPs-8/9) quantified at each time point. Longitudinal analysis revealed that in group-A, the MMP-8/-9 levels were decreased at T2 compared with at T0 (P = 0.013 and P = 0.004, respectively) and that the MMP-9 levels were decreased at T1 (P = 0.004). These reductions were not significant in group-B. The CRP levels in both groups did not change over time. No between-group differences were noted for any parameter. The correlation between the full-mouth bleeding score and the MMP-8 level in both groups was significant (P < 0.001). The investigated local and systemic inflammatory parameters were not affected by the tested multimicronutrient supplement in patients who adhered to MD. In conclusion, MMP-8 is useful for assessing the reduction in periodontal inflammation.</p>
Journal
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- Journal of Oral Science
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Journal of Oral Science 61 (2), 213-220, 2019
Nihon University School of Dentistry
