Shorter Leukocyte Telomere Length Is Associated With Atrial Remodeling and Predicts Recurrence in Younger Patients With Paroxysmal Atrial Fibrillation After Radiofrequency Ablation

• Pan Kuo-Li

  Division of Cardiology, Chang Gung Memorial Hospital School of Traditional Chinese Medicine, College of Medicine, Chang Gung University

• Hsiao Ya-Wen

  Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital

• Lin Yenn-Jiang

  Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital School of Medicine, Faculty of Medicine, National Yang-Ming University

• Lo Li-Wei

  Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital School of Medicine, Faculty of Medicine, National Yang-Ming University

• Hu Yu-Feng

  Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital School of Medicine, Faculty of Medicine, National Yang-Ming University

• Chung Fa-Po

  Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital School of Medicine, Faculty of Medicine, National Yang-Ming University

• Tsai Yung-Nan

  Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital School of Medicine, Faculty of Medicine, National Yang-Ming University

• Chao Tze-Fan

  Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital School of Medicine, Faculty of Medicine, National Yang-Ming University

• Liao Jo-Nan

  Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital School of Medicine, Faculty of Medicine, National Yang-Ming University

• Lin Chin-Yu

  Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital School of Medicine, Faculty of Medicine, National Yang-Ming University

• Jhuo Shih-Jie

  Division of Cardiology, Kaohsiung Medical University Hospital

• Lin Chung-Hsing

  Division of Cardiology, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University

• Suresh Allamsetty

  Department of Cardiology, Nizam’s Institute of Medical Sciences

• Walia Rohit

  Division of Cardiology, Medanta Heart Institute, Medanta The Medicity

• Te Abigail Louise D.

  Heart Institute, St. Luke’s Medical Center

• Yamada Shinya

  Department of Cardiology and Hematology, Fukushima Medical University

• Chang Yao-Ting

  Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital School of Medicine, Faculty of Medicine, National Yang-Ming University

• Chang Shih-Lin

  Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital School of Medicine, Faculty of Medicine, National Yang-Ming University

• Chen Shih-Ann

  Division of Cardiology, Department of Medicine, Taipei Veterans General Hospital School of Medicine, Faculty of Medicine, National Yang-Ming University

抄録

Background:Telomere length is a biologic aging marker. This study investigated leukocyte telomere length (LTL) as a new biomarker to predict recurrence after paroxysmal atrial fibrillation (PAF) ablation. Methods and Results:A total of 131 participants (26 healthy individuals and 105 symptomatic PAF patients) were enrolled. PAF patients (54.1±10.8 years) who received catheter ablation therapy were divided into 2 groups: recurrent AF (n=25) and no recurrent AF after catheter ablation (n=80). Peripheral blood mononuclear cells were collected from all subjects to measure LTL. Under 50 years old, LTL in healthy individuals (n=17) was longer than in PAF patients (n=31; 7.34±0.58 kbp vs. 6.44±0.91 kbp, P=0.01). In PAF patients, LTL was positively correlated with left atrial bipolar voltage (R=0.497, P<0.001), and negatively correlated with biatrial scar area (R=−0.570, P<0.001) and left atrial diameter (R=−0.214, P=0.028). LTL was shorter in the patients with recurrent AF than in those without recurrent AF after catheter ablation (5.68±0.82 kbp vs. 6.66±0.71 kbp; P<0.001). On receiver operating characteristic curve analysis, LTL cut-off <6.14 kbp had a specificity of 0.68 and sensitivity of 0.79 to predict recurrent AF after catheter ablation. Conclusions:Young PAF patients (≤50 years) had shorter LTL. Shorter LTL was associated with a degenerative atrial substrate and recurrence after catheter ablation in younger PAF patients.

収録刊行物

• Circulation Journal

  Circulation Journal 83 (7), 1449-1455, 2019-06-25

  一般社団法人 日本循環器学会

キーワード

• Atrial fibrillation
• Catheter ablation
• Leukocyte telomere length

詳細情報

• CRID: 1390001288147258752
• NII論文ID: 130007666961
• NII書誌ID: AA11591968
• DOI: 10.1253/circj.cj-18-0880
• ISSN: 13474820
• ISSN: 13469843
• NDL書誌ID: 029762221
• PubMed: 31118363
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I029762221
• Web Site: https://www.jstage.jst.go.jp/article/circj/83/7/83_CJ-18-0880/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2020032292
• 本文言語コード: en
• データソース種別:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
• 抄録ライセンスフラグ: 使用不可