Acylated ghrelin levels were associated with depressive status, physical quality of life, endoscopic findings based on Kyoto classification in Japan
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- Agawa Shuhei
- Department of Internal Medicine, Division of Gastroenterology, Nippon Medical School
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- Futagami Seiji
- Department of Internal Medicine, Division of Gastroenterology, Nippon Medical School
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- Yamawaki Hiroshi
- Department of Internal Medicine, Division of Gastroenterology, Nippon Medical School
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- Ikeda Go
- Department of Internal Medicine, Division of Gastroenterology, Nippon Medical School
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- Noda Hiroto
- Department of Internal Medicine, Division of Gastroenterology, Nippon Medical School
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- Kirita Kumiko
- Department of Internal Medicine, Division of Gastroenterology, Nippon Medical School
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- Higuchi Kazutoshi
- Department of Internal Medicine, Division of Gastroenterology, Nippon Medical School
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- Murakami Makoto
- Department of Internal Medicine, Division of Gastroenterology, Nippon Medical School
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- Kodaka Yasuhiro
- Department of Internal Medicine, Division of Gastroenterology, Nippon Medical School
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- Ueki Nobue
- Department of Internal Medicine, Division of Gastroenterology, Nippon Medical School
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- Akamizu Takashi
- The First Department of Medicine, Wakayama Medical University
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- Iwakiri Katsuhiko
- Department of Internal Medicine, Division of Gastroenterology, Nippon Medical School
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Abstract
<p>Background and Aims: To determine whether serum acylated ghrelin levels were associated with anxiety, clinical symptoms, depressive status, quality of life, gastric motility and endoscopic findings based on Kyoto classification in functional dyspepsia (FD) patients. Methods: We enrolled three groups, FD patients (n = 15) with high levels of acylated ghrelin, FD patients (n = 33) with normal levels of acylated ghrelin and FD patients (n = 35) with low levels of acylated ghrelin. There was no significant differences in the positivity of Helicobacter pylori infection among the three groups. Clinical symptoms were evaluated by Gastrointestinal Symptom Rating Scale (GSRS) and FD symptoms based on Rome III classification. Acylated ghrelin levels were measured by ELISA methods. Depressive status, anxiety, sleep disturbance were respectively asscessed by Self-rating questionnaire for depression (SRQ-D) score, STAI-state/-trait, Pittsburgh sleep quality index (PSQI) scores. Endoscopic findings were evaluated based on Kyoto classification. Results: Body Mass Index (BMI) in FD patients with low levels of acylated ghrelin was significantly higher (p<0.001 and p = 0.008, respectively) compared to those in FD patients with high and normal levels of acylated ghrelin. SRQ-D scores in FD patients with low levels of acylated ghrelin was significantly lower (p = 0.008 and p<0.001, respectively) compared to those in FD patients with high and normal levels of acylated ghrelin. Scoring of gastric atrophy, intestinal metaplasia, xanthoma and mucus based on Kyoto classification in FD patients with low levels of acylated ghrelin were significantly higher (p<0.001, p = 0.0077, p = 0.036 and p = 0.0063, respectively) compared to those in FD patients with more than low levels of acylated ghrelin. Conclusion: Acylated ghrelin levels were associated with BMI, depressive status, and endoscopic findings based on Kyoto classification in FD patients.</p>
Journal
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- Journal of Clinical Biochemistry and Nutrition
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Journal of Clinical Biochemistry and Nutrition 65 (1), 65-70, 2019
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Details 詳細情報について
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- CRID
- 1390845713081244032
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- NII Article ID
- 130007672109
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- ISSN
- 18805086
- 09120009
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- Text Lang
- en
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed