Growth Inhibition of Human Breast and Prostate Cancer Cells by Cinnamic Acid Derivatives and Their Mechanism of Action

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  • Imai Masahiko
    Laboratory of Physiological Chemistry, Institute of Medicinal Chemistry, Hoshi University
  • Yokoe Hiromasa
    Laboratory of Bioorganic Chemistry, Institute of Medicinal Chemistry, Hoshi University
  • Tsubuki Masayoshi
    Laboratory of Bioorganic Chemistry, Institute of Medicinal Chemistry, Hoshi University
  • Takahashi Noriko
    Laboratory of Physiological Chemistry, Institute of Medicinal Chemistry, Hoshi University

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<p>Cancer is the leading cause of death and there is a particularly pressing need to develop effective treatments for breast and prostate cancer. In the current study, we show the inhibitory effects of cinnamic acid derivatives, including caffeic acid phenethyl ester (CAPE, 1), on the growth of breast and prostate cancer cells. Among the compounds examined, 3,4,5-trihydroxycinnamic acid decyl ester (6) showed the most potent inhibition of cancer cell growth by the induction of apoptosis. Compound 6 could be a new anti-cancer agent for use against breast and prostate cancer.</p>

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