Growth Inhibition of Human Breast and Prostate Cancer Cells by Cinnamic Acid Derivatives and Their Mechanism of Action

• Imai Masahiko

  Laboratory of Physiological Chemistry, Institute of Medicinal Chemistry, Hoshi University

• Yokoe Hiromasa

  Laboratory of Bioorganic Chemistry, Institute of Medicinal Chemistry, Hoshi University

• Tsubuki Masayoshi

  Laboratory of Bioorganic Chemistry, Institute of Medicinal Chemistry, Hoshi University

• Takahashi Noriko

  Laboratory of Physiological Chemistry, Institute of Medicinal Chemistry, Hoshi University

Abstract

Cancer is the leading cause of death and there is a particularly pressing need to develop effective treatments for breast and prostate cancer. In the current study, we show the inhibitory effects of cinnamic acid derivatives, including caffeic acid phenethyl ester (CAPE, 1), on the growth of breast and prostate cancer cells. Among the compounds examined, 3,4,5-trihydroxycinnamic acid decyl ester (6) showed the most potent inhibition of cancer cell growth by the induction of apoptosis. Compound 6 could be a new anti-cancer agent for use against breast and prostate cancer.

Journal

• Biological and Pharmaceutical Bulletin

  Biological and Pharmaceutical Bulletin 42 (7), 1134-1139, 2019-07-01

  The Pharmaceutical Society of Japan

Keywords

• cinnamic acid
• caffeic acid phenethyl ester
• breast cancer
• prostate cancer
• apoptosis

Details

• CRID: 1390564238103012736
• NII Article ID: 130007672142
• NII Book ID: AA10885497
• DOI: 10.1248/bpb.b18-01002
• ISSN: 13475215
• ISSN: 09186158
• NDL BIB ID: 029761825
• PubMed: 30982786
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I029761825
• Web Site: https://www.jstage.jst.go.jp/article/bpb/42/7/42_b18-01002/_pdf
• Web Site: https://search.jamas.or.jp/link/ui/2020109261
• Text Lang: en
• Data Source:
  • JaLC
  • NDL
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed