Improving the Prediction of Protein Structural Class for Low-Similarity Sequences by Incorporating Evolutionary and Structural Information
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- Kong Liang
- School of Mathematics and Information Science & Technology, Hebei Normal University of Science & Technology School of Information Science and Engineering, Yanshan University
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- Kong Lingfu
- School of Information Science and Engineering, Yanshan University
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- Jing Rong
- School of Information Science and Engineering, Yanshan University
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抄録
<p>Protein structural class prediction is beneficial to study protein function, regulation and interactions. However, protein structural class prediction for low-similarity sequences (i.e., below 40% in pairwise sequence similarity) remains a challenging problem at present. In this study, a novel computational method is proposed to accurately predict protein structural class for low-similarity sequences. This method is based on support vector machine in conjunction with integrated features from evolutionary information generated with position specific iterative basic local alignment search tool (PSI-BLAST) and predicted secondary structure. Various prediction accuracies evaluated by the jackknife tests are reported on two widely-used low-similarity benchmark datasets (25PDB and 1189), reaching overall accuracies 89.3% and 87.9%, which are significantly higher than those achieved by state-of-the-art in protein structural class prediction. The experimental results suggest that our method could serve as an effective alternative to existing methods in protein structural classification, especially for low-similarity sequences.</p>
収録刊行物
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- Journal of Advanced Computational Intelligence and Intelligent Informatics
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Journal of Advanced Computational Intelligence and Intelligent Informatics 20 (3), 402-411, 2016-05-20
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詳細情報 詳細情報について
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- CRID
- 1390564238103232768
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- NII論文ID
- 130007673423
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- NII書誌ID
- AA12042502
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- ISSN
- 18838014
- 13430130
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- NDL書誌ID
- 027302824
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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- CiNii Articles
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- 使用不可