Methylmercury causes neuronal cell death via M1-microglial activation in organotypic slices prepared from mouse cerebral cortex
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- Hoshi Takayuki
- Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University
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- Toyama Takashi
- Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University
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- Naganuma Akira
- Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University
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- Hwang Gi-Wook
- Laboratory of Molecular and Biochemical Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University
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<p>Methylmercury is an environmental pollutant that causes central nervous system injury. We reported that the expression of the inflammatory cytokines TNF-α and IL-1β was specifically induced in the brains of methylmercury-treated mice. In addition, we recently found that cytotoxic microglia (M1-microglia) may be involved in the induction of inflammatory cytokine expression by methylmercury in mouse cerebral slice cultures. In the current study, we investigated the involvement of M1-microglia in the neuronal cell death caused by methylmercury using mouse cerebral slice cultures. The results revealed that methylmercury activated steady state microglia (M0-microglia) to M1-microglia, but this activation was suppressed by pretreatment with minocycline, a microglial activation inhibitor. In addition, under the same conditions, minocycline suppressed neuronal cell death by methylmercury. These results suggest that methylmercury may induce neuronal cell death via activation to M1-microglia.</p>
収録刊行物
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- Fundamental Toxicological Sciences
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Fundamental Toxicological Sciences 6 (5), 167-170, 2019
一般社団法人 日本毒性学会
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詳細情報 詳細情報について
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- CRID
- 1390845713080006144
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- NII論文ID
- 130007674519
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- ISSN
- 2189115X
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
- KAKEN
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- 抄録ライセンスフラグ
- 使用不可