Stanford大学Eric T. Kool研究室への留学—核酸のケミカルバイオロジー—  [in Japanese] Study at the Kool Lab in Stanford University —Chemical Biology of Nucleic Acid—  [in Japanese]

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Author(s)

    • 田原 優樹 Tahara Yuki
    • 味の素株式会社イノベーション研究所フロンティア研究所先端融合研究グループ New Frontiers Research Group, Frontier Research Labs, Institute for Innovation, Ajinomoto Co., Inc.

Abstract

<p>Earned a chance to study chemical biology of nucleic acid at Stanford University. I show why did I decide to study abroad, how did I choose a labolatory to join, and what did I feel and acquire in the lab, Silicon Valley and the US. As for the research project at Stanford, I focused on DNA repair, its enzyme and inhibitors. The interface of chemistry and biology using chemistry-based tools and strategies is quite effective to provide potentially useful materials and new technologies for next generation science. In particular, biochemical applications/material sciences with synthetic nucleic acids, DNA and RNA have growth potential, and they are one of the most attactive fields. This article describes the chemical biology tool with fluorescent DNA probe for detection of 8-oxoguanine DNA glycosylase activity, and the structure-activity relationships of the inhibitors by synthesizing a broad range of analogues. The best inhibitor SU0268 was synthesized by straightforward process from commercially available starting materials and shown to be selective for inhibiting the enzyme, and displayed no toxicity in human cell lines.</p>

Journal

  • Journal of Synthetic Organic Chemistry, Japan

    Journal of Synthetic Organic Chemistry, Japan 77(7), 724-731, 2019

    The Society of Synthetic Organic Chemistry, Japan

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