Assessment of Concentrations of Four Phenothiazine Antipsychotics in Serum and Whole Blood Using Different Diatomaceous Earth-based Solid-phase Columns: A Comparative Analysis

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  • SAITO Takeshi
    Department of Emergency and Critical Care Medicine, Tokai University School of Medicine
  • NAMERA Akira
    Department of Forensic Medicine, Graduate School of Biomedical and Health Sciences, Hiroshima University
  • TSUJI Tomoatsu
    Department of Emergency and Critical Care Medicine, Tokai University School of Medicine
  • INOKUCHI Sadaki
    Department of Emergency and Critical Care Medicine, Tokai University School of Medicine

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Abstract

<p>This study attempted to determine the phenothiazine antipsychotics concentration in serum and whole blood samples using various diatomaceous earth-based solid-phase columns and elution solvents and subsequently evaluate their efficiency. Phenothiazine antipsychotics concentrations of 5 – 2000 ng/mL were extracted from serum and whole blood using each column. All compounds were analyzed using liquid chromatography–tandem mass spectrometry. Phenothiazine antipsychotics extraction in serum and whole blood using diatomaceous earth-based solid-phase columns seemed to have an affinity with the elution solvent.</p>

Journal

  • Analytical Sciences

    Analytical Sciences 35 (7), 815-819, 2019-07-10

    The Japan Society for Analytical Chemistry

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